Mapping urban form into local climate zones for the continental US from 1986-2020.

Urbanization has altered land surface properties driving changes in micro-climates. Urban form influences people's activities, environmental exposures, and health. Developing detailed and unified longitudinal measures of urban form is essential to quantify these relationships.

Land surface and air temperature dynamics: The role of urban form and seasonality.

Due to the scarcity of air temperature (T) observations, urban heat studies often rely on satellite-derived Land Surface Temperature (LST) to characterise the near-surface thermal environment. However, there remains a lack of a quantitative understanding on how LST differs from T within urban areas and what are the controlling factors of their interaction. We use crowdsourced air temperature measurements in Sydney, Australia, combined with urban landscape data, Local Climate Zones (LCZ), high-resolution satellite imagery, and machine learning to explore the influence of urban form and fabric on the interaction between T and LST.

Spatial distribution of atmospheric microplastics in bulk-deposition of urban and rural environments - A one-year follow-up study in northern Germany.

Atmospheric microplastic deposition rates play a crucial role for calculating the input of microplastics in the environment and to further understand pollution patterns. In this study, the spatial and temporal distribution of atmospheric microplastic particles in urban and rural areas of Northern Germany was investigated. Therefore, eleven structurally diverse locations in Hamburg and Mecklenburg-Western Pomerania were equipped with bulk-deposition samplers in triplicates and sampled monthly between August 2019 and July 2020.

Soil texture mediates the surface cooling effect of urban and peri-urban green spaces during a drought period in the city area of Hamburg (Germany).

Urban green spaces (UGS) and peri-urban green spaces (P-UGS) play a crucial role in reducing the land surface temperature within the urban environment, especially during heat waves. Although their cooling effect generally is due to shading and evaporation, the role of soil texture and soil water availability on surface cooling remains largely unexplored. This study investigated the impact of soil texture on the spatio-temporal patterns of LST in different UGSs and P-UGSs in Hamburg (Germany) during a hot summer drought period.

Background climate modulates the impact of land cover on urban surface temperature.

Cities with different background climates experience different thermal environments. Many studies have investigated land cover effects on surface urban heat in individual cities. However, a quantitative understanding of how background climates modify the thermal impact of urban land covers remains elusive.

Combining expert and crowd-sourced training data to map urban form and functions for the continental US.

Although continental urban areas are relatively small, they are major drivers of environmental change at local, regional and global scales. Moreover, they are especially vulnerable to these changes owing to the concentration of population and their exposure to a range of hydro-meteorological hazards, emphasizing the need for spatially detailed information on urbanized landscapes. These data need to be consistent in content and scale and provide a holistic description of urban layouts to address different user needs.

Mapping Europe into local climate zones.

Cities are major drivers of environmental change at all scales and are especially at risk from the ensuing effects, which include poor air quality, flooding and heat waves. Typically, these issues are studied on a city-by-city basis owing to the spatial complexity of built landscapes, local topography and emission patterns. However, to ensure knowledge sharing and to integrate local-scale processes with regional and global scale modelling initiatives, there is a pressing need for a world-wide database on cities that is suited for environmental studies.

Public housing and healthcare use: an investigation using linked administrative data.

Objective: This study investigated whether a move to public housing affects people's use of healthcare services.

Method: Using administrative data from Manitoba, the number of hospitalizations, general practitioner (GP), specialist and emergency department (ED) visits, and prescription drugs dispensed in the years before and after the housing move-in date (2012/2013) were measured for a public housing and matched cohort. Generalized linear models with generalized estimating equations tested for differences between the cohorts in utilization trends.

Changes in healthcare use among individuals who move into public housing: a population-based investigation.

Background: Residence in public housing, a subsidized and managed government program, may affect health and healthcare utilization. We compared healthcare use in the year before individuals moved into public housing with usage during their first year of tenancy. We also described trends in use.

Non-persistence and non-adherence to long-acting COPD medication therapy: A retrospective cohort study based on a large German claims dataset.

Objectives: The main objectives of this study, based on a large cohort of German COPD patients, were to assess the level of non-persistence (NP) and non-adherence (NA) with long-acting COPD inhaler treatment and to describe factors that may be associated with NP and NA.

Methods: This was a retrospective cohort analysis based on claims data provided by a German statutory health insurance fund (years 2010-2012). NP was analyzed for treatment-naïve patients only; it was defined as a gap of >90 days in medication availability.

Health and social predictors of applications to public housing: a population-based analysis.

Background: Residents of public housing are often in poor health. However, it is unclear whether poor health precedes residency in public housing. We compared the health of people who applied to public housing to people who did not apply and had similar socioeconomic characteristics.

Assessing asthma severity based on claims data: a systematic review.

Introduction: Asthma is one of the most common chronic diseases in Germany. Substantial economic evaluation of asthma cost requires knowledge of asthma severity, which is in general not part of claims data. Algorithms need to be defined to use this data source.

Healthcare costs and resource utilization of asthma in Germany: a claims data analysis.

Introduction: Asthma is associated with a substantial economic burden on the German Statutory Health Insurance.

Aims And Objectives: To determine costs and resource utilization associated with asthma and to analyze the impact of disease severity on subgroups based on age and gender.

Methods: A claims database analysis from the statutory health insurance perspective was conducted.

Burden of corticosteroid use in patients with systemic lupus erythematosus: results from a Delphi panel.

Corticosteroid-related adverse events (AEs) are commonly reported in systemic lupus erythematosus (SLE), but are often under-represented in claims data. The most common corticosteroid-related AEs are not necessarily the most costly. The present study aimed to examine corticosteroid-related AE rates and identify the associated cost consequences in patients with SLE from the perspective of rheumatologists treating SLE in the United States (US).

Utilization of bedside urogenital ultrasound in an austere combat setting: enterovesicular fistula case report.

The role of bedside ultrasound by physicians with advanced ultrasound training, such as emergency medicine providers, has been clearly established in the austere setting of combat medicine. This highly mobile, noninvasive, and versatile imaging modality has a role in evaluating battle- and nonbattle-related presentations. This case report describes a U.

Cumulative burden of oral corticosteroid adverse effects and the economic implications of corticosteroid use in patients with systemic lupus erythematosus.

Background: Corticosteroids (CSs) are used to treat patients with systemic lupus erythematosus (SLE) and are associated with potential adverse events (AEs). However, few data are currently available on the risk of AEs in CS users in an SLE population.

Objective: To examine AEs related to CS use and costs of treating CS-related AEs in patients with SLE.

Healthcare utilization and costs of systemic lupus erythematosus in Medicaid.

Objective. Healthcare utilization and costs associated with systemic lupus erythematosus (SLE) in a US Medicaid population were examined. Methods.

Twenty-five statements on early initiation of fixed combination ICS/LABA treatment for asthma and COPD in primary and secondary care: consensus research by a modified Delphi process.

Background: Guidelines recommend the addition of a long-acting β2-agonist (LABA) for patients whose asthma is uncontrolled on inhaled corticosteroid (ICS) monotherapy. For COPD patients the addition of an ICS to a long-acting bronchodilator is recommended for symptomatic patients at high risk of exacerbations. We examined whether in real-life practice guideline recommendations may delay optimal timing for initiation of combination treatment.

Superior vena cava syndrome masquerading as an allergic reaction.

Patients are often referred to the emergency department for further evaluation, yet the astute physician will maintain a broad differential to avoid anchoring on prior diagnoses. In this case, a 56-year-old man was referred to our emergency department from the radiology suite secondary to concerns for an “allergic reaction” to prior magnetic resonance imaging contrast. Upon presentation, he was noted to have facial swelling with ruddy appearance and vascular congestion extending to the midchest region; no airway compromise or dyspnea was noted.

Observational study on the impact of initiating tiotropium alone versus tiotropium with fluticasone propionate/salmeterol combination therapy on outcomes and costs in chronic obstructive pulmonary disease.

Background: This retrospective cohort study compared the risks of exacerbations and COPD-related healthcare costs between patients with chronic obstructive pulmonary disease (COPD) initiating tiotropium (TIO) alone and patients initiating triple therapy with fluticasone-salmeterol combination (FSC) added to TIO.

Methods: Managed-care enrollees who had an index event of ≥ 1 pharmacy claim for TIO during the study period (January 1, 2003-April 30, 2008) and met other eligibility criteria were categorized into one of two cohorts depending on their medication use. Patients in the TIO+FSC cohort had combination therapy with TIO and FSC, defined as having an FSC claim on the same date as the TIO claim.

Treatments for reversing warfarin anticoagulation in patients with acute intracranial hemorrhage: a structured literature review.

Study Objective: The acute management of patients on warfarin with spontaneous or traumatic intracranial hemorrhage continues to be debated in the medical literature. The objective of this paper was to conduct a structured review of the medical literature and summarize the advantages and risks of the available treatment options for reversing warfarin anticoagulation in patients who present to the emergency department with acute intracranial hemorrhage.

Methods: A structured literature search and review of articles relevant to intracranial hemorrhage and warfarin and treatment in the emergency department was performed.

Detection of a t(4;14)(p16;q32) in two cases of lymphoma showing both the immunophenotype of chronic lymphocytic leukemia.

Reciprocal IGH/14q32 translocations are detectable in 55-70% of patients with plasma cell myeloma; e.g., the adverse t(4;14)(p16;q32) fusing the IGH and FGFR3 genes (immunoglobulin heavy chain/fibroblast growth factor receptor 3).

Spin-spin coupling and substituent and halogen isotope shift effects in the fluorine NMR spectra of fluorinated cyclopropanes and cyclopropyl ethers.

The (19)F NMR spectra of a series of fluorinated cyclopropanes, most of which contain chlorine or bromine on the ring, have been observed and analyzed. A scheme has been developed to assign the resonances and the molecular stereochemistry, based on substituent effects, comparison of related molecules, and isotope shifts induced by the halogens. Replacement of fluorine by chlorine shifts cis fluorine resonances to lower field, and bromine has an even greater downfield influence.

Kinematics of the transition between aquatic and terrestrial locomotion in the newt Taricha torosa.

California newts (Taricha torosa) are capable of locomotion in both aquatic and terrestrial environments. The transition between swimming and terrestrial walking was examined by videotaping individual Taricha walking both up and down a ramp, inclined at 15 degrees to the horizontal, that had its lower end immersed in water and its upper end out of the water. When ascending the ramp, California newts first approached it by swimming, then used their limbs to walk while still in water, and finally left the water using a normal terrestrial walking gait.

The use of nuclear magnetic resonance for assessment of time variation in composition of human milk and colostrum: a case study during pregnancy and post-partum.

Nuclear Magnetic Resonance (NMR) Spectra were collected on milk and colostrum obtained from the author during the pregnancy and post-partum periods for two births. Peak features in the downfield region, containing antibody and aromatic resonances (6.0 to 9.