Effects of probucol on the cholesterol content of skin in type II hyperlipoproteinemias.

500 mg of probucol were given twice a day for 6 months to 20 type II hyperlipoproteinemic patients, 14 men and 6 women, including 10 type IIb and 10 type IIa cases. Tendon xanthomas were present in 11 and xanthelasma in 4. Their mean blood cholesterol level was 435 +/- 100 mg/100 ml and triglycerides 210 +/- 138 mg/100 ml.

[Type II familial hyperlipoproteinaemia : value of plasma exchange treatment (author's transl)].

A 13-year-old boy with homozygous type II familial hyperlipoproteinaemia with marked cutaneous and tendinous xanthomatosis has been followed-up for a 3-year period. Signs of unstable angina developed at the age of 14 years, followed by the onset of a posterodiaphragmatic infarction at 16 years-ion. The usual poor spontaneous prognosis, and the lack of efficacy of medical treatment on blood cholesterol levels, led to suggest the use of plasmapheresis.

Study of free and esterified cholesterol in skin in atherogenic hyperlipidemias.

Free and esterified cholesterol in the skin were assayed by gas chromatography after thin layer histochromatographic separation. There were 20 controls of both sexes, 36 subjects with type lla hyperlipoproteinemia, 27 with type IIb hyperlipoproteinemia and 19 with type IV hyperlipoproteinemia. Esterified skin cholesterol levels were higher in women with the type of lla disorder and in subjects with tendinous xanthomas.

Power considerations in epidemiologic studies of vinyl chloride workers.

Nine retrospective mortality studies of workers exposed to vinyl chloride were reviewed to determine whether differences in their hypothesis testing results might be due to differences in statistical power. Where possible, the power of each study was calculated for cancer of the lung, brain and liver. When power was taken into consideration, the results for liver and brain cancer were found to be consistent with an etiologic role for vinyl chloride.

[Immunoglobulins and hyperlipoproteinemias].

With the objective of detecting autoimmune hyperlipidemias (AIH) we looked for the immunoglobulins bound to the low-density lipoproteins (test Ig-Lp): in 50 normolipidemic subjects and, in 133 hyperlipoproteinemic patients: 43 of type IIa, 34 of type IIb, 36 of type IV and 20 of Type V. The Ig-Lp was negative in the 50 normolipidemic subjects. It was positive in 26 hyperlipoproteinemic cases, including; 5 of type IIA, 3 of type IIb, 7 of type IV and 11 of type V.

[Vascular thrombosis in synthetic estrogen-progestogen users: an immune mechanism (author's transl)].

In a number of women the use of combined oral contraceptives (OC) may induce the production of anti-ethinylestradiol antibodies circulating as immune complexes (IC) and which precipitate when the serum is brought at 25% saturation in ammonium sulphate. Testing for tests ICs in 50 women who had never taken OCs, in 100 women on OCs but otherwise healthy, and in 17 women on OCs presenting with vascular thrombosis showed that 20% of all healthy women and more than 95% of women with thrombosis were immunoreactive. The statistically significant correlation found between thrombosis and the presence in the serum of ICs and anti-ethinylestradiol antibodies suggests that an immune mechanism might be responsible for the vascular lesions induced by oral contraceptives containing synthetic estrogens.

[Hypertriglyceridemia and tumors. Production of stable cultures of Green's lymphoma].

In Golden Hamster the Greene malignant lymphoma is a subcutaneous and homotransplantable tumor whose development is associated with a constant hypertriglyceridemia and a large-decreased plasma post-heparin lipase activity. The tumoral cell line is well maintained on a human fibroblast monolayer culture and is demonstrated to secrete two IgG immunoglobulins.

[Free and esterified cholesterol of the skin in atherogenic hyperlipidemias].

Skin free and esterified cholesterol were assayed using gaseous chromatography following plaque histochromatography separation in 20 control, 36 patients with Type II a hyperlipoproteinemia, 27 with Type II b hyperlipoproteinemia and 19 with Type IV hyperlipoproteinemia. Skin esterified cholesterol was higher in females with Type II a hyperlipoproteinemia without or with xanthomatosis. But the skin esterified cholesterol level was not correlated with skin free cholesterol nor with blood total cholesterol levels, while in males these parameters were well correlated.

[Detection of pill-induced antiethinylestradiol antibodies (author's transl)].

The synthetic hormones contained in contraceptive pills were shown to induce antiethinylestradiol (EE) antibodies in some women. These antibodies can be detected by the presence of circulating immune complexes (CIC) which are precipitated from serum in 25 p. cent saturated ammonium sulphate.

Vascular thrombosis and oral contraceptives - a risk correlated study.

An immunological mechanism of the vascular complications related to oral contraceptives (O.C.) was suggested by the demonstration of circulating anti-ethinylestradiol antibodies in several cases.

Mortality of welders, shipfitters, and other metal trades workers in boilermakers Local No. 104, AFL-CIO.

The mortality experience of 8679 members of a metal trades union--men employed in shipyards, metal fabrication shops, small boat yards, and field construction--was studied from 1950 to 1976 by the historical prospective method. Relative to rates for US men of comparable age and race, the risk of death from all causes combined was 0.99.

Purification of a monoclonal IgA with antiheparin activity.

A monoclonal IgA with antiheparin activity was obtained from a hyperlipidemic plasma. For the separation of the IgA antibody the plasma was passed through a column of Bio-Gel P-6 to eliminate the unbound heparin. As a second step, intervent dilution chromatography was used.

[Effects of probucol on skin cholesterol concentrations in patients with type II hyperlipoproteineamia (author's transl)].

Twenty patients (14 male and 6 female) with hyperlipoproteineamia (type IIa in 10 and type IIb in 10) were given probucol 500 mg b.d. during 6 months.

Attentional bias and visual field asymmetry.

In mixed list tachistoscopic presentation of abstract words and random shapes, the probability of word and shape stimuli was varied to generate attentional bias and selective activation of the left or right hemispheres. While a right visual field advantage in accuracy was observed for words, and an effect of stimulus probability was observed across both visual fields in reaction time, no interactions were found between attentional bias and visual field asymmetry. The results can therefore be explained without reference to the attentional model and did not provide evidence of hemispheric activation or priming.

Antilipoprotein autoimmune hyperlipidemia. The Ig-Lp test.

In the antilipoprotein type of autoimmune hyperlipidemia (AIH), the immunoglobulins (Ig) are bound to lipoproteins by their antibody site and circulate as immune Ig-Lp complexes. In the earlier studies, the specific antibody activities were demonstrated in vitro by specific but rather sophisticated methods which were not suitable for the screening of antilipoprotein AIH in large populations. In the Ig-Lp test described here, the immunoglobulins bound to the low density lipoproteins (Ig-Lp) are detected by floating the complexes at D 1.

[Treatment of prostatic cancer with diethylstilboestrol and detection of the vascular risk (author's transl)].

A retrospective study of immunologic behavior of patients suffering from cancer of the prostate and treated with oestrogens permits the proposal of the utilisation of a test that separates a high thromboembolic risk population due to oestrogens from a population that can benefit from this hormonotherapy. The so-called "oestrogen tolerance test" consists of seeking the presence of immune complexes by the method of precipitation of serum by 25% saturated ammonium sulphate. The group of patients where precipitates exceeds 700 micrograms/ml has a thrombo-embolic risk above 30% (41% in our series with serious complications such as pulmonary embolus and arterial thrombosis.

Ethinylestradiol and diethylstilbestrol induced antibodies and vascular thrombosis.

Antiethinylestradiol antibodies were demonstrated in several oral contraceptive users. The antibodies could be precipitated from serum immune complexes by 25% saturated ammonium sulfate. This test of serum precipitation was applied to a comparative study of 116 women on O.