Characterization of dynamic compliance of the respiratory system in healthy anesthetized dogs.

Introduction: In clinical practice, evaluating dynamic compliance of the respiratory system (C) could provide valuable insights into respiratory mechanics. Reference values of C based on body weight have been reported, but various factors may affect them and the evidence is scanty. This study aimed to establish a reference interval for C and identify associated variables.

Making Surgery as Safe as It Should Be: A Qualitative Study.

Existing literature supports the view that adverse outcomes from surgical interventions are more likely to be the result of degraded nontechnical skills (NTS) rather than the technical skills of surgeons. In the present context, NTS comprise the behaviors and cognitions deployed by surgeons to make decisions, maintain awareness of the operating environment, communicate with and lead supporting personnel. A contemporary safety thesis suggests that focusing on what makes things go right (eg, NTS) is far more productive than retrospective analysis (learning from mistakes).

A Scoping Review of Three Dimensions for Long-Term COVID-19 Vaccination Models: Hybrid Immunity, Individual Drivers of Vaccinal Choice, and Human Errors.

The virus that causes COVID-19 changes over time, occasionally leading to Variants of Interest (VOIs) and Variants of Concern (VOCs) that can behave differently with respect to detection kits, treatments, or vaccines. For instance, two vaccination doses were 61% effective against the BA.1 predominant variant, but only 24% effective when BA.

MicroRNA expression profiling of hypothalamic arcuate and paraventricular nuclei from single rats using Illumina sequencing technology.

MicroRNAs (miRNAs) finely tune messenger RNA (mRNA) expression. As the brain is a highly heterogeneous tissue, physiologically relevant miRNA expression profiling greatly benefits from sampling brain regions or nuclei. MiRNA expression profiling from individual samples is also important for investigating potential differences between animals according to their physiological and pathophysiological status.

Decreasing phantom limb pain through observation of action and imagery: a case series.

Background: Phantom limb pain is often resistant to treatment. Techniques based on visual-kinesthetic feedback could help reduce it.

Objective: The objective of the current study was to test if a novel intervention combining observation and imagination of movements can reduce phantom limb pain.

Anthrax in a Scottish intravenous drug user.

Anthrax, caused by Bacillus anthracis, is an uncommon disease in the United Kingdom. In December 2009, the first recorded case of injectable anthrax in the UK was diagnosed in Glasgow, Scotland. This case report describes the disease presentation in a detained person in police custody in Dumfries, South West Scotland.

Effect of intrapartum antibiotic prophylaxis against group B streptococcal infection on comparisons of rates of endometritis and urinary tract infection in multicenter surveillance.

Objective: To establish whether antibiotic prophylaxis against group B streptococcal infection may be a confounding factor in comparisons of rates of endometritis and urinary tract infection after vaginal delivery.

Design: Prospective study.

Setting: Maternity units at 48 hospitals in a regional surveillance network in France during 2001-2004.

Automatism and hypoglycaemia.

A case of a detained person (DP) suffering from insulin-dependent diabetes, who subsequently used the disorder in his defence as a reason to claim automatism, is discussed. The legal and medical history of automatism is outlined along with the present day situation. Forensic physicians should be aware when examining any diabetic that automatism may subsequently be claimed.

Is it epilepsy?

Detainees in police stations frequently claim to suffer from epilepsy. The diagnosis of epilepsy is not always straight forward and a misdiagnosis can be easily made, even by specialists. The case of a detained person claiming to suffer from epilepsy is described.

Blood from a line - Is it admissible?

The Police Reform Act 2002 enables blood to be lawfully taken from any driver who has been involved in a road traffic accident, who lacks the capacity to consent as a result of a medical problem or injury, and who may be under the influence of alcohol or drugs. Consent at the time is not required but must be obtained at a later date. Experience of forensic physicians suggest obtaining blood directly from a vein, as the Act requires, can sometimes be technically difficult in an intensive care setting.

Body on the beach...a case of foot and mouth?

The case of a missing person is described whose body was discovered almost 8 months later on a secluded beach on the Solway coast, south west Scotland. The delay in discovery was due to the foot and mouth outbreak in the UK in 2001 and this resulted in conditions favouring the development of partial mummification. The influence of the tides and involvement of HM Coastguard are discussed, along with difficulties in the identification of partially skeletonised remains.

Antipsychotics--the future of schizophrenia treatment.

Schizophrenia is a debilitating mental disorder affecting up to five in every thousand people. Although specialist psychiatrists are initially responsible for treating patients suffering from acute schizophrenia, the current structure of mental healthcare in the U.K.

Aspiration and sampling efficiencies of the TSP and louvered particulate matter inlets.

An experimental system was developed for the rapid measurement of the aspiration/transfer efficiency of aerosol samplers in a wind tunnel. We attempted to measure the aspiration and particle transfer characteristics of two inlets commonly used for sampling airborne Particulate Matter (PM): the 'Total Suspended Particulate' or TSP inlet, and the louvered 'dichotomous sampler inlet' typically used in sampling PM10 or PM2.5.

[In utero transfer for preterm labor: experience of a regional perinatal hotline providing a 24-hour on call service].

Objective: Preterm labor is one of the major causes of concern for level I and II obstetricians. The purpose of this study was to determine the incidence of in utero transfer performed for preterm labor. We also aimed to evaluate the algorithm we used in case of call for preterm labor.

Autobiographical memory, depression and quality of life in multiple sclerosis.

The relationship between autobiographical memory, depression and quality of life (QoL) was investigated in a study of 30 persons with severe neurodisability resulting from multiple sclerosis. Sixty percent (n = 18) of patients were found to have deficits in autobiographical memory (AMI) for incidents in their earlier life; these deficits were associated with significant impairments in personal semantic memory of facts from their past life. Patients with impaired autobiographical memory who had been diagnosed for longer than 21 years reported significantly better QoL (SF-36: Role Physical) than those diagnosed more recently, or those with normal autobiographical memory; patients who had been diagnosed for longer were also significantly less depressed than patients diagnosed more recently.

[Routine use of electronic portal imaging. Positioning verification in 922 successive pelvic fields].

Treatment reproducibility is a major criterion of quality assurance in radiation therapy. During each course, the same dose should be delivered in the same volume of irradiation. Today, portal imaging devices can be used routinely to check and correct patient positioning before much of the daily irradiation has been delivered.

A randomized, double-blind, multi-centre, parallel-group study comparing the tolerability and efficacy of moclobemide and dothiepin hydrochloride in depressed patients in general practice.

A randomized, double-blind, multi-centre, parallel-group study compared the tolerability and efficacy of 450 mg of moclobemide and 75-150 mg of dothiepin in the management of depressed patients in general practice. Patients who fulfilled the DSM-III-R criteria for major depressive disorder and who scored 13 or more on the Hamilton Depression Rating Scale were admitted. The trial lasted six weeks.

The SmithKline Beecham 'quality of life' scale: a validation and reliability study in patients with affective disorder.

The rationale for the development of Repertory-Grid based quality of life assessment (QOL) is described. The emergent scale, the SmithKline Beecham Quality of Life Scale (SBQOL) utilizes 23 predetermined constructs and three fixed elements: self now, ideal self and sick self. Inclusion of the latter two elements provides a personal frame of reference for the individual and recognizes the highly idiosyncratic and subjective nature of the experience which constitutes quality of life.