Publications by authors named "Beau D Jernberg"
Article Synopsis
- Cell surface signaling (CSS) in Gram-negative bacteria modulates transcription in response to external stimuli, specifically through the pseudobactin BN7/8 uptake system, which also regulates its own transcription.
- The PupB and PupR proteins form a periplasmic complex that remains inactive in the absence of iron, and recent crystal structure studies have allowed exploration of the effects of specific mutations on this complex.
- Experimental techniques like NMR and calorimetry show that while mutations (Q69K, H72D, L74A) reduce thermal stability and weaken binding interactions, they do not significantly change the overall structure of PupB’s N-terminal signaling domain.
Cell-surface signaling (CSS) in Gram-negative bacteria involves highly conserved regulatory pathways that optimize gene expression by transducing extracellular environmental signals to the cytoplasm via inner-membrane sigma regulators. The molecular details of ferric siderophore-mediated activation of the iron import machinery through a sigma regulator are unclear. Here, we present the 1.
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