Publications by authors named "Beatriz de los Santos"
Bioactive properties of spearmint, orange peel, and baby sage oleoresins obtained by supercritical CO extraction and their integration into dark chocolate.
Food Chem
January 2025
This study investigated the potential health benefits of spearmint, orange peel, and baby sage oleoresins extracted using supercritical CO and subsequently emulsified. The oleoresins were incorporated into dark chocolate, and their impact on physicochemical properties was evaluated. Characterization revealed rich sources of phenolic compounds, carotenoids, and volatile compounds in these oleoresins.
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- The study focused on understanding the global historical and genetic relationships between Merino sheep and their derived breeds by genotyping 19 populations and analyzing additional data from 23 populations.
- Several statistical tests confirmed that the genetic diversity in Merino breeds is influenced by their geographic origin and local admixture, particularly highlighting the impact of Australian, Rambouillet, and German strains.
- The research identified 106 candidate genes under potential selection, including those related to immune response, growth, morphology, and reproductive traits, indicating the genetic adaptations of Merino sheep to different climates.
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- Müller glial cells in the retina have the ability to behave as stem cells, promoting regeneration more effectively in lower vertebrates than in mammals like rodents, where progenitor cells lose this ability soon after birth.
- This study shows that, when grown with Müller glial cells, rat retina progenitor cells retained their stem cell properties, allowing them to proliferate and differentiate into mature photoreceptors even after multiple passaging.
- Key findings indicate that Müller glial cells not only help generate new photoreceptors but also support a population of undifferentiated cells to maintain stem cell features, potentially enhancing the limited regeneration seen in mammalian retinas.
The finding that Müller cells have stem cell properties in the retina has led to the hypothesis that they might be a source for replacing neurons lost in neurodegenerative diseases. However, utilization of Müller cells for regenerative purposes in the mammalian eye still requires identifying those factors that regulate their multipotentiality and proliferation. In addition, because Pax6 expression is indispensable for eye development, its regulation would be required during regeneration.
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