Publications by authors named "Beatriz Maria Assis-Brasil"
Article Synopsis
- Papillary thyroid cancer (PTC) is more common in women, with studies suggesting estrogen's role in increasing this incidence, particularly through 17β-estradiol (E2) affecting thyroid cell behavior.
- The study focuses on G protein estrogen receptor 1 (GPER1) gene and protein expression in PTC versus non-malignant thyroid tissues, revealing lower GPER1 levels in PTC and its association with clinical features like metastasis, female gender, and BRAF mutations.
- Results indicate that GPER1 may influence PTC tumorigenesis and suggests it could be a potential target for therapy, calling for more research into its functions in both normal and cancerous thyroid tissues.
Activity of ecto-5'-nucleotidase (NT5E/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes.
Ana Paula Santin Bertoni Paula Andreghetto Bracco Rafael Paschoal de Campos Bruna Schwengber Lutz Beatriz Maria Assis-Brasil
Mol Cell Endocrinol
January 2019
Article Synopsis
- The study investigates the role of the NT5E gene in papillary thyroid carcinoma (PTC) and its potential as a therapeutic target.
- Significant differences in AMP hydrolysis and NT5E expression were found between PTC cells and normal thyroid cells, indicating a potential link to tumor progression.
- Higher NT5E levels correlated with clinical features like larger tumor size and the presence of metastatic lymph nodes in PTC patients.