Relapsed or refractory acute myeloid leukemia (AML) remains a major therapeutic challenge. We have recently developed a Vδ1+ γδ T cell-based product for adoptive immunotherapy, named Delta One T (DOT) cells, and demonstrated their cytolytic capacity to eliminate AML cell lines and primary blasts in vitro and in vivo. However, the molecular mechanisms responsible for the broad DOT-cell recognition of AML cells remain poorly understood.
View Article and Find Full Text PDFRev Assoc Med Bras (1992)
January 2022
Objective: Risk stratification of sudden cardiac death in patients with coronary artery disease is of great importance. We evaluated the association between ventricular repolarization and induction of malignant ventricular arrhythmias on electrophysiological study of patients with coronary artery disease.
Methods And Results: A total of 177 patients (65±10.
Crowns made from an yttria-stabilized tetragonal zirconia polycrystals (3Y-TZP) core with a porcelain veneer have shown high clinical failure rates. Manifestations of clinical failure in veneering ceramic ranges from a single chip to an extended fracture. Core failures are uncommon but usually are catastrophic.
View Article and Find Full Text PDFPurpose: To assess the current situation of white enamel lesions on vestibular surfaces of permanent maxillary incisors, diagnosed 6 years ago, without clinical intervention.
Materials And Methods: The prospective study reassessed 53 students of both sexes, aged between 13 and 18 years old, all attending the public school system in Natal, Brazil. Data collection was performed by calibrated examiners, and a clinical chart consisting of demographic data on dental caries, oral hygiene and gingival condition was prepared.