Dual function of Langerhans cells in skin TSLP-promoted T differentiation in mouse atopic dermatitis.

Background: Atopic dermatitis (AD) is among the most common chronic inflammatory skin diseases, usually occurring early in life, and often preceding other atopic diseases such as asthma. T2 has been believed to play a crucial role in cellular and humoral response in AD, but accumulating evidence has shown that follicular helper T cell (T), a critical player in humoral immunity, is associated with disease severity and plays an important role in AD pathogenesis.

Objectives: This study aimed at investigating how Ts are generated during the pathogenesis of AD, particularly what is the role of keratinocyte-derived cytokine TSLP and Langerhans cells (LCs).