Publications by authors named "Beatriz Candas-Estebanez"
Metabolic syndrome (MetS) is associated with alterations of lipoprotein structure and function that can be characterized with advanced lipoprotein testing (ADLT). The effect of the Mediterranean diet (MedDiet) and weight loss on the lipoprotein subclass profile has been scarcely studied. Within the PREDIMED-Plus randomized controlled trial, a sub-study conducted at Bellvitge Hospital recruiting center evaluated the effects of a weight loss program based on an energy-reduced MedDiet (er-MedDiet) and physical activity (PA) promotion (intervention group) compared with energy-unrestricted MedDiet recommendations (control group) on ADLT-assessed lipoprotein subclasses.
View Article and Find Full Text PDFBackground: Genetic risk scores (GRSs) have partially improved the understanding of the etiology of moderate hypertriglyceridemia (HTG), which until recently was mainly assessed by secondary predisposing causes. The main objective of this study was to assess whether this variability is due to the interaction between clinical variables and GRS. Methods: We analyzed 276 patients with suspected polygenic HTG.
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- The study investigates the connection between genetic factors, subclinical atherosclerosis, and abnormal lipoproteins in women with Systemic Lupus Erythematosus (SLE), a condition linked to higher cardiovascular risk.
- 73 women with SLE were compared to 73 age-matched controls through serum analysis, atherosclerosis screening, and genetic testing of specific genes.
- Results indicated that women with SLE had higher triglyceride levels and a greater likelihood of carotid atherosclerosis, with the rs1260326 gene variant showing a significant association with increased cardiovascular risk.
SLE is associated with increased cardiovascular risk. The objective of this study was to determine the prevalence of asymptomatic carotid atherosclerosis to analyze its relationship with dyslipidemia and related genetic factors in a population of patients with SLE. Seventy-one SLE female patients were recruited.
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- Hypertriglyceridaemia (HTG) is a common condition affecting 15%-20% of the global population, often detected incidentally during lab tests.
- HTG can be categorized into two genetic types: monogenic (very high levels) and polygenic (moderate levels), with many patients still lacking a clear genetic cause.
- Understanding the genetic factors behind HTG has led to new treatment options that go beyond strict low-fat diets, as high triglyceride levels are linked to an increased risk of cardiovascular disease.
Objectives: Few data are available regarding follow up of patients with coronavirus disease 2019 (COVID-19) after their discharge. We aim to describe the long-term outcomes of survivors of hospitalization for COVID-19 followed up first at an outpatient facility and subsequently by telephone.
Methods: Observational prospective study conducted at a tertiary general hospital.
Article Synopsis
- Some lipoprotein disorders linked to premature cardiovascular disease (PCVD) are not identified by standard lipid tests.
- A case-control study involving 125 PCVD patients and 190 controls assessed the predictive value of serum small dense LDL cholesterol (sdLDL-C) and other lipoprotein characteristics using advanced techniques like nuclear magnetic resonance (NMR).
- PCVD patients exhibited lower total LDL particles but higher levels of sdLDL-C and specific triglycerides, revealing that these factors are strong predictors of PCVD, highlighting the need for more detailed lipoprotein analysis beyond conventional profiles.
Background: Lipid metabolism disorders, especially hypertriglyceridemia (HTG), are risk factors for non-alcoholic fatty liver disease (NAFLD). However, the association between genetic factors related to HTG and the risk of NAFLD has been scarcely studied.
Methods: A total of 185 subjects with moderate HTG were prospectively included.
Background: LDL-C lowering is the main measure in cardiovascular disease prevention but a residual risk of ischemic events still remains. Alterations of lipoproteins, specially, increase in small dense LDL (sdLDL) particles are related to this risk.
Objective: To investigate the potential use of sdLDL cholesterol concentration (sdLDL-C) isolated by an easy precipitation method and to assess the impact of a set of clinical and biochemical variables determined by NMR on sdLDL concentration.
Article Synopsis
- Statin therapy effectiveness varies widely among patients, with genetic variants in lipid metabolism genes and medications potentially influencing responses, though many impacts are not yet confirmed.* -
- A study involving 252 patients examined how specific gene variants (ABCA1, CYP2D6, CETP) affect responses to statins like simvastatin, atorvastatin, and rosuvastatin, particularly focusing on lipid target achievements.* -
- Findings indicated that certain variants are linked to poorer outcomes with statins, suggesting that genetic testing could eventually guide personalized statin choices for better health results.*
Article Synopsis
- The study aimed to examine the ovarian reserve in women with BRCA1 and BRCA2 mutations by measuring anti-mullerian hormone levels, and how these levels affect reproductive outcomes.
- It involved 135 women, including those with BRCA mutations and healthy controls, and the results showed mutation-positive women had lower anti-mullerian hormone levels compared to mutation-negative and other carriers.
- Despite the lower hormone levels in mutation-positive women, infertility rates did not significantly differ among the groups, suggesting that mutation status may not have a profound impact on fertility.
To assess the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) supplementation on bone metabolism in HIV-infected patients presenting with hypertriglyceridemia. Patients were randomized 1:1 to receive 2 g of n-3 PUFA or fenofibrate (FF). The primary endpoint was % change in bone mineral density (BMD) from baseline to month 24 in lumbar spine (LS) and femoral neck (FN).
View Article and Find Full Text PDFIntroduction: The therapeutic response to statins has a high interindividual variability with respect to reductions in plasma LDL-cholesterol (c-LDL) and increases in HDL cholesterol (c-HDL). Many studies suggest that there is a relationship between the rs20455 KIF6 gene variant (c.2155T> C, Trp719Arg) and a lower risk of cardiovascular disease in patients being treated with statins.
View Article and Find Full Text PDFBackground: Lipemia, a significant source of analytical errors in clinical laboratory settings, should be removed prior to measuring biochemical parameters. We investigated whether lipemia in serum/plasma samples can be removed using a method that is easier and more practicable than ultracentrifugation, the current reference method.
Methods: Seven hospital laboratories in Spain participated in this study.
Article Synopsis
- Patients with dyslipidemia often use statins to lower cholesterol and reduce cardiovascular risk, but their response can vary due to genetic factors.
- This study investigated how six specific gene variants affect statin effectiveness in reducing total and non-HDL cholesterol in 100 patients who hadn't been treated before.
- The results indicated that the HMGCR c.1564-106A > G variant significantly reduced the effectiveness of statins, making it harder for patients to reach cholesterol targets.
Reference values assessment in a Mediterranean population for small dense low-density lipoprotein concentration isolated by an optimized precipitation method.
Vasc Health Risk Manag
September 2017
Article Synopsis
- High serum concentrations of small dense low-density lipoprotein cholesterol (sd-LDL-c) are linked to increased cardiovascular disease risk, but quantification is currently complicated.
- A new optimized, simpler precipitation method for isolating sd-LDL particles was developed and tested against the standard ultracentrifugation process, showing no significant differences in results.
- Reference intervals for sd-LDL-c concentrations were established for a Mediterranean population, helping to improve the clinical application of sd-LDL-c measurement.
Background: The APOE Christchurch (APOECh) is a rare variant (c.543C>A) in codon 154. It was first described in an E2 patient with type III dyslipidemia, and thus initially called E2Ch.
View Article and Find Full Text PDFIntroduction: Most of the cost-effectiveness analyses are based on estimations to make decisions on the future implementation of a test. However, the model should be verified with real data to prove that previous estimations have been successfully fulfilled.
Objective: To study the economic impact of the systematic HLA-B*57:01 genotyping in preventing hypersensitivity reactions (HSRs) in the patient population of a tertiary-care hospital treated with abacavir (ABC) using retrospective data of 5 years of experience.
The VII European Symposium of the Clinical Laboratory and In Vitro Diagnostic Industry, co-organized between the Catalan Association for Clinical Laboratory Sciences (ACCLC) and the Catalan Society of Biology, was held on May 28th-29th, 2013 in Barcelona (Catalonia, Spain) under the IFCC auspices and the IUPAC sponsorship. The subject of the present Symposium was "Molecular Genetics in the Clinical Laboratory" and began with an opening conference that was a stroll through the history of molecular genetics in the context of the clinical laboratory. The scientific program was structured in several 2-h length roundtables that dealt with the following topics: recent advances in molecular genetics for clinical microbiology, latest evidences and real applicability of pharmacogenetics in the clinical practice, quality assurance of a molecular genetics laboratory, and latest trends in prenatal genetic diagnosis.
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