Publications by authors named "Beatriz Calvo-Serra"
Article Synopsis
- Researchers have found that microproteins from noncanonical open reading frames (ncORFs) can produce tumor-specific antigens during cancer progression, potentially triggering immune responses.
- By analyzing RNA sequencing and other data from 117 liver cancer (hepatocellular carcinoma) tumors, they discovered that about 40% of these antigens likely come from ncORFs, including some that can initiate an immune response in humanized mice.
- The study also identified 33 long noncoding RNAs that express shared cancer antigens found in over 10% of the samples, suggesting new possibilities for developing cancer vaccines.
Human metabolism is influenced by genetic and environmental factors. Previous studies have identified over 23 loci associated with more than 26 urine metabolites levels in adults, which are known as urinary metabolite quantitative trait loci (metabQTLs). The aim of the present study is the identification for the first time of urinary metabQTLs in children and their interaction with dietary patterns.
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