Publications by authors named "Beatriz A Llamas-Guillen"
Importance: There is growing understanding that Social Determinants of Health (SDH) impact on the outcomes of different pediatric conditions. We aimed to determine whether SDH affect the severity of MIS-C.
Design: Retrospective cohort study, 2021-2023.
Article Synopsis
- The study aimed to investigate the epidemiology and outcomes of multisystem inflammatory syndrome in children (MIS-C) across 16 Latin American countries from August 2020 to June 2022.
- Out of 1239 children with MIS-C, the majority were previously healthy, with common symptoms including abdominal pain and conjunctival injection, and nearly half required intensive care.
- The overall death rate was 4.88%, notably higher for those not initially diagnosed with MIS-C, emphasizing the need for improved awareness and early detection of the syndrome.
Article Synopsis
- Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 shows varied severity, with a lower mortality rate in wealthier countries, highlighting differences in outcomes across regions.
- In a study of 1,239 children across 16 Latin American countries, the majority were previously healthy, but nearly half required admission to the pediatric intensive care unit (PICU), where they experienced more severe symptoms like myocardial dysfunction.
- Key risk factors for PICU admission included being over six years old, experiencing shock or seizures, having low platelet counts, elevated inflammatory markers, and abnormalities on chest X-rays, with an overall mortality rate of 4.8%, which is notably higher than in high-income countries.
Article Synopsis
- * The study, involving 13 hospitals, found that the majority of patients (88%) were male, all experienced bacterial infections, and 30% had fungal infections; complications related to the BCG vaccine occurred in 58% of vaccinated patients.
- * Genetic analysis revealed X-linked CGD was most common, with 89% diagnosed biologically and 89% genetically; notable findings include a significant presence of CYBA and NCF2 mutations,
Severe combined immunodeficiency (SCID) represents the most lethal form of primary immunodeficiency, with mortality rates of greater than 90% within the first year of life without treatment. Hematopoietic stem cell transplantation and gene therapy are the only curative treatments available, and the best-known prognostic factors for success are age at diagnosis, age at hematopoietic stem cell transplantation, and the comorbidities that develop in between. There are no evidence-based guidelines for standardized clinical care for patients with SCID during the time between diagnosis and definitive treatment, and we aim to generate a consensus management strategy on the supportive care of patients with SCID.
View Article and Find Full Text PDFDr. Tomisaku Kawasaki was the first to describe BCG reactivation in Kawasaki Disease (K), and this sign is present in about 30-50% of K patients. It is a very specific early sign of the disease and although it has been recognized for decades, its pathophysiology continues to be an enigma.
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