Publications by authors named "Beatrix Uberheide"
Article Synopsis
- The Borg5 protein, part of the Borg family, normally promotes stress fibers and contractility but actually limits these functions in mature MDCK cell layers.
- Depleting Borg5 disrupts the lateral arrangement of F-actin, encourages microtubule-dependent lamellae, and causes uneven shapes of cell surfaces in tightly packed cells.
- Borg5 reduces the interaction between septin proteins and microtubules and also interacts with myosin IIA, suggesting it counters septin activity to control contractility in MDCK cells.
Pol II(G) is a distinct form of RNA polymerase II that contains the tightly associated Gdown1 polypeptide (encoded by POLR2M). Unlike Pol II, Pol II(G) is highly dependent upon Mediator for robust activator-dependent transcription in a biochemically defined in vitro system. Here, in vitro studies show that Gdown1 competes with TFIIF for binding to the RPB1 and RPB5 subunits of Pol II, thereby inhibiting an essential function of TFIIF in preinitiation complex assembly, but also that Mediator can actually facilitate Pol II(G) binding to the promoter prior to subsequent Mediator functions.
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