Publications by authors named "Beatrice Quirion"
Article Synopsis
- - Primary afferent neurons transmit pain signals from harmful stimuli to the spinal cord, with mu and delta opioid receptors (MOP and DOP) playing crucial roles in pain relief and being found in dorsal root ganglia (DRG) neurons.
- - The study used techniques like in situ hybridization and immunofluorescence to observe the distribution of MOP and DOP receptors in mice and rats, finding that both are present in various types of neurons, but with different expression levels.
- - Results indicated that DOP is mainly found in large and medium myelinated neurons, while MOP predominantly appears in C fibers; interestingly, the distribution varies slightly between species, though neither morphine nor inflammation altered these
Nowadays, pain represents one of the most important societal burdens. Current treatments are, however, too often ineffective and/or accompanied by debilitating unwanted effects for patients dealing with chronic pain. Indeed, the prototypical opioid morphine, as many other strong analgesics, shows harmful unwanted effects including respiratory depression and constipation, and also produces tolerance, physical dependence, and addiction.
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