Hyperthyroidism and clinical depression: a systematic review and meta-analysis.

Hyperthyroidism and clinical depression are common, and there is preliminary evidence of substantial comorbidity. The extent of the association in the general population, however, has not yet been estimated meta-analytically. Therefore we conducted this systematic review and meta-analysis (registered in PROSPERO: CRD42020164791).

Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis.

Importance: Hypothyroidism is considered a cause of or a strong risk factor for depression, but recent studies provide conflicting evidence regarding the existence and the extent of the association. It is also unclear whether the link is largely due to subsyndromal depression or holds true for clinical depression.

Objective: To estimate the association of hypothyroidism and clinical depression in the general population.