Publications by authors named "Beatrice Fervers"

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  • * The study focused on the relationship between long-term dietary mycotoxin exposure and hepatobiliary cancers in the EPIC cohort, using detailed food occurrence data to assess risks.
  • * Findings indicated a significant link between higher intake of the mycotoxin deoxynivalenol (DON) and hepatocellular carcinoma risk, suggesting further research is needed on mycotoxins and their potential health impacts.
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  • Breast cancer is the most common cancer in women, and environmental pollutants, particularly endocrine disruptors like dioxins, may influence its development.
  • A study analyzed the link between airborne dioxin exposure and breast cancer risk in a cohort of 5222 cases and 5222 controls, using data about their proximity to dioxin sources and other factors.
  • The results indicate a slight increase in breast cancer risk with higher cumulative dioxin exposure, suggesting the need for measures to reduce air pollution exposure.
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Background: Growing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.

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  • A study examined the link between bilirubin levels in the blood and colorectal cancer (CRC) risk in 78,467 Korean adults aged 40-78, focusing on differences between sexes and non-linear relationships.
  • Findings showed that higher total bilirubin levels were associated with a 26% lower risk of CRC when comparing the highest and lowest levels, with a notable U-shaped relationship in men.
  • The research concluded that elevated levels of both total and indirect bilirubin are linked to a reduced risk of CRC, particularly in men, while the findings in women were less significant.
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Introduction: Adolescents and young adults (AYA) with cancer undergo physical transformations due to disease and treatments occurring alongside puberty and adolescence. Although physical activity is recommended for its benefits, its practice among AYA with cancer remains insufficient. The aim of the Éducation Thérapeutique et Activité Physique: Engagement des Adolescents et Jeunes Adultes atteints de cancer study is to identify the evolution of AYA with cancer medical knowledge and powers (power to act, to express oneself) over life and cancer care, and their role in commitment in adapted physical activity (APA) and therapeutic patient education during and after oncological treatments.

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Background: Physical activity reduces colorectal cancer risk, yet the diurnal timing of physical activity in colorectal cancer etiology remains unclear.

Methods: This study used 24-h accelerometry time series from UK Biobank participants aged 42 to 79 years to derive circadian physical activity patterns using functional principal component analysis. Multivariable Cox proportional hazard models were used to examine associations with colorectal cancer risk.

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Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect.

Objective: To identify distinct long term trajectories of exposure to PCB153 and BaP, and estimate their associations with breast cancer risk.

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Background: Women with breast cancer face many barriers to return to work (RTW) after their cancer. The main objective of the FASTRACS-RCT is to evaluate the impact of the FASTRACS (Facilitate and Sustain Return to Work after Breast Cancer) intervention on the sustainable RTW of breast cancer patients, 12 months after the end of active treatment.

Methods: FASTRACS-RCT is a prospective, national, multicentre, randomized, controlled and open-label study.

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  • Next-generation sequencing techniques, like whole-exome and error-corrected sequencing, are used to analyze mutation patterns in both cancerous and non-cancerous tissues.
  • The review emphasizes the potential of using these techniques on archived tissue samples fixed in formalin or alcohol to identify mutational signatures that reflect prior exposure to mutagens.
  • By distinguishing between DNA damage from tissue fixation and true biological mutations, this research helps improve our understanding of cancer causes and supports prevention strategies aimed at reducing exposure to cancer risk agents.
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Background: An increasing evidence links air pollution to breast cancer (BC) risk. Yet, pollutant exposure estimates at the workplace location in pollution exposure assessment have not been considered.

Objectives: This study investigates the association between particulate matters (PM, PM) and nitrogen dioxide (NO) atmospheric concentrations (1990-2011), at the women's residential and workplace locations, and BC risk.

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Background: Human exposure to air pollution involves complex mixtures of multiple correlated air pollutants. To date, very few studies have assessed the combined effects of exposure to multiple air pollutants on breast cancer (BC) risk.

Objectives: We aimed to assess the association between combined exposures to multiple air pollutants and breast cancer risk.

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Epidemiological studies on health effects of air pollution usually estimate exposure at the residential address. However, ignoring daily mobility patterns may lead to biased exposure estimates, as documented in previous exposure studies. To improve the reliable integration of exposure related to mobility patterns into epidemiological studies, we conducted a systematic review of studies across all continents that measured air pollution concentrations in various modes of transport using portable sensors.

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Outdoor exposure to particulate matter (PM and PM) in urban areas can vary considerably depending on the mode of transport. This study aims to quantify this difference in exposure during daily travel, by carrying out a micro-sensor measurement campaign. The pollutant exposure was assessed simultaneously over predefined routes in order to allow comparison between different transport modes having the same starting and ending points.

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Background: While overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialized countries, especially in non-smoking and non-drinking patients.

Case Presentation: We document a case of gingiva SCC in a 56 years old never-smoker patient reporting low alcohol consumption and unusual occupational solvent exposure. The HPV-negative lesion was surgically removed in 2018, and the patient remains in complete remission 4 years after recurrent surgery in 2019.

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  • - The study investigates the combined effects of four air pollutants with endocrine-disrupting properties (benzo-[a]-pyrene, cadmium, dioxin, and PCB153) on breast cancer risk, noting that most research typically looks at each pollutant individually.
  • - Using statistical methods like weighted quantile sum and quantile g-computation, the researchers found a positive association between exposure to pollutant mixtures and increased breast cancer risk, though one method (BKMR) showed less statistical significance.
  • - The findings suggest that joint exposure to these pollutants may contribute to breast cancer risk, with specific pollutants like benzo-[a]-pyrene and cadmium showing stronger associations, while dioxin displayed an inverse trend.
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It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with CRC risk in observational analyses in 329,828 UK Biobank participants (3728 cases).

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Objectives: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of occupational exposure to solvents on the risk of developing TGCT among young men.

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This article describes some of the key prevention services in the Leon Berard Comprehensive Cancer Center (CLB) Lyon, France, which are based on clinical prevention services, outreach activities, and collaboration with professional and territorial health communities. In addition, research is embedded at all stages of the prevention continuum, from understanding cancer causes through to the implementation of prevention interventions during and after cancer. Health promotion activities in the community and dedicated outpatient primary cancer prevention services for individuals at increased risk have been implemented.

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Acute exercise induces transient modifications in the tumor microenvironment and has been linked to reduced tumor growth along with increased infiltration of immune cells within the tumor in mouse models. In this study, we aimed to evaluate the impact of acute exercise before treatment administration on tumor growth in a mice model of MC38 colorectal cancer receiving an immune checkpoint inhibitor (ICI) and chemotherapy. Six-week-old mice injected with colorectal cancer cells (MC38) were randomized in 4 groups: control (CTRL), immuno-chemotherapy (TRT), exercise (EXE) and combined intervention (TRT/EXE).

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WHAT LEVERS FOR PRIMARY PREVENTION? Facing the continuous increase in cancer incidence, mobilizing efficient levers to act upstream of the disease is a major public health issue. Accelerating the transfer into practice of the continuous enrichment of the understanding of the multifactorial causes of cancers constitutes a first lever of prevention. This also requires a strengthening of the involvement of all actors and stakeholders, beyond the health and medico-social sectors.

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Background: Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT.

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Background: Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15-40 years, with increasing incidence worldwide. About 33 ~ 50% of the patients present with metastatic disease at diagnosis. TGCT survivors experience short- and long-term sequelae, including cancer-related fatigue (CRF).

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