Publications by authors named "Beate Roese-Koerner"
Canonical Notch signaling has diverse functions during nervous system development and is critical for neural progenitor self-renewal, timing of differentiation and specification of various cell fates. A key feature of Notch-mediated self-renewal is its fluctuating activity within the neural progenitor cell population and the oscillatory expression pattern of the Notch effector Hes1 and its target genes. A negative feedback loop between Hes1 and neurogenic microRNA miR-9 was found to be part of this oscillatory clock.
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- The balance between self-renewal and differentiation in neural stem cells is essential for proper neural development, and is influenced by Notch signaling and the microRNA miR-9/9(∗).
- MiR-9/9(∗) promotes differentiation by reducing Notch activity through targeting specific genes, while Notch signaling negatively regulates differentiation and simultaneously promotes miR-9/9(∗) expression.
- This interplay between miR-9/9(∗) and Notch signaling highlights a complex relationship that helps maintain the balance necessary for human neural stem cell function.
The impressive neuronal diversity found within the nervous system emerges from a limited pool of neural progenitor cells that proceed through different gene expression programs to acquire distinct cell fates. Here, we review recent evidence indicating that microRNAs (miRNAs) are critically involved in conferring neural cell identities during neural induction, neuronal differentiation and subtype specification. Several studies have shown that miRNAs act in concert with other gene regulatory factors and genetic switches to regulate the spatial and temporal expression profiles of important cell fate determinants.
View Article and Find Full Text PDFMicroRNAs are key regulators of neural cell proliferation, differentiation and fate choice. Due to the limited access to human primary neural tissue, the role of microRNAs in human neuronal differentiation remains largely unknown. Here, we use a population of long-term self-renewing neuroepithelial-like stem cells (lt-NES cells) derived from human embryonic stem cells to study the expression and function of microRNAs at early stages of human neural stem cell differentiation and neuronal lineage decision.
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