Different evolutionary modifications as a guide to rewire two-component systems.

Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The aim of this study is to better understand and describe rewiring of TCS while investigating different evolutionary scenarios.

Performance groups in adult cochlear implant users: speech perception results from 1984 until today.

Introduction: More than 3,000 patients have received a cochlear implant in Hannover.

Methods: A group of 864 patients was selected from the main group for the analysis of speech perception development. Depending on the term of introduction of new implant technology, the viewed group was divided into 5 subgroups.

Current steering and results from novel speech coding strategies.

Objective: Advanced Bionics' cochlear implants have independent current sources that can share stimulation current between 2 contacts (Current Steering). By stimulating 2 adjacent electrodes with different weights, different pitches can be evoked, allowing to increase the number of processing channels.

Study Design: A counterbalanced crossover design was used to compare 3 different current steering implementations to the clinical HiRes strategy.

Evaluation of the Harmony soundprocessor in combination with the speech coding strategy HiRes 120.

Objective: The Advanced Bionics Harmony BTE processor was developed to support the new speech coding strategy HiRes 120 with a resolution of 120 channels based on "current steering." Compared with the previous Auria, the front end has been re-designed and power consumption reduced.

Study Design: HiRes 120 as well as the impact of the improved Harmony processing concerning a better speech understanding were evaluated.