Publications by authors named "Beate Kristmann"
Article Synopsis
- Targeting acute myeloid leukemia (AML) with CAR-T cells is complex due to the widespread expression of AML antigens in healthy cells and the variability between different patients and even within the same patient's tumor cells.
- Single-cell analysis of 30 pediatric AML samples highlighted CD33, CD38, CD371, IL1RAP, and CD123 as key antigens, underscoring the need for multiple targeting strategies.
- The study introduces a modular Adapter CAR platform that allows for flexible and effective targeting of these antigens, showing that combining targets can lead to better treatment outcomes in heterogeneous AML populations.
Article Synopsis
- Understanding the tumor immune microenvironment (TIME) is crucial for developing better cancer therapies, and multiplexed tissue imaging is a key tool for studying this complexity.
- A comprehensive immunophenotyping panel with over 121 markers was created using advanced imaging techniques to analyze primary cancer tissues, focusing on tumor heterogeneity and immune cell interactions.
- The study revealed important findings about the interactions between immunosuppressive myeloid cells and exhausted T cells in hepatocellular carcinoma, demonstrating the value of spatial profiling in uncovering clinically relevant tumor features.
