Prospective, Observational Study of Aflibercept Use in Combination with FOLFIRI in Patients with Metastatic Colorectal Cancer: A Real-World Effectiveness Study.

Background: This was an observational study prospectively evaluating the effectiveness and safety of aflibercept/FOLFIRI administered in second-line mCRC per the reimbursement criteria in Poland.

Methods: Consecutive mCRC patients who progressed with first-line oxaliplatin-based chemotherapy received aflibercept (4 mg/kg IV) followed by FOLFIRI every 2 weeks until progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS); overall survival (OS) and safety were the secondary endpoints.

Effect of different drying conditions for the viability of Candida albicans present on carriers.

Background: Problems in substantial under recovery of Pseudomonas aeruginosa and Candida albicans from carriers have been demonstrated for laboratories performing phase 2, step 2 efficacy tests on disinfectants relative to levels required by the EN 13697 standard. It was thus necessary to determine recoveries of these microorganisms following procedural losses incurred during drying and to optimise drying conditions such that recoveries then complied with the standard.

Objectives: The aim of the study was to establish optimal drying conditions for the recovery of Candida albicans ATCC 10231 from carriers.

Recommendations for thermal disinfection based on the A0 concept according to EN ISO 15883.

The use of aseptic instruments for the care of patients is an essential element in the prevention of nosocomial infections. Significant risks have been associated with inadequate or improper cleaning and disinfection of reusable medical devices. Thermal disinfection with moist heat, based on the A0 concept (EN ISO 15883-1), is the most common method for disinfection of medical devices in the hospital setting.