Gubernaculum and Epididymo-Testicular Descent: Review of the Literature.

Cryptorchidism is a common disorder in boys that has been widely studied both experimentally and clinically. The role of the gubernaculum, a mesenchymal tissue extending from the fetal testis and epididymis to the developing scrotum, is still unclear. Even the name is debated: 'gubernaculum epididymis' or 'gubernaculum testis'.

Abnormal histology in testis from prepubertal boys with monorchidism.

Background: Little is known about the histology of contralateral descended testes in boys with unilaterally absent testis. We investigated whether absence of one testis is associated with abnormal tissue architecture of the solitary contralaterally descended testis.

Design Setting And Patients: For this retrospective study, we examined the results of biopsies of the contralateral descended testis in 43 boys with monorchidism.

Testicular expression of long non-coding RNAs is affected by curative GnRHa treatment of cryptorchidism.

Background: Cryptorchidism is a frequent endocrinopathy in boys that has been associated with an increased risk of developing testicular cancer and infertility. The condition is curable by combined surgery and hormonal treatment during early pre-pubertal stages using gonadotropin releasing hormone agonist (GnRHa). However, whether the treatment also alters the expression of testicular long non-coding RNAs (lncRNAs) is unknown.

Gonadotropin-Releasing Hormone Agonist Corrects Defective Mini-Puberty in Boys with Cryptorchidism: A Prospective Randomized Study.

Introduction: This prospective study investigated the efficacy of a gonadotropin-releasing hormone agonist (LH-RHa) in restoring defective mini-puberty.

Materials And Methods: Boys with isolated bilateral cryptorchidism and defective mini-puberty were randomly divided into two groups. The "surgery only" group underwent a second orchidopexy without hormonal treatment (control).