Publications by authors named "Beata Roka"
Elderly patients have increased susceptibility to acute kidney injury (AKI). Long noncoding RNAs (lncRNA) are key regulators of cellular processes, and have been implicated in both aging and AKI. Our aim was to study the effects of aging and ischemia-reperfusion injury (IRI) on the renal expression of lncRNAs.
View Article and Find Full Text PDF(1) Background: Ischemia reperfusion (IR) is the leading cause of acute kidney injury (AKI) and results in predisposition to chronic kidney disease. We demonstrated that delayed contralateral nephrectomy (Nx) greatly improved the function of the IR-injured kidney and decelerated fibrosis progression. Our aim was to identify microRNAs (miRNA/miR) involved in this process.
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- The study investigates how lipopolysaccharide (LPS)-induced inflammation impacts miRNA expression in the kidneys during septic acute kidney injury (AKI) at different time points.
- Male mice were treated with LPS, and their kidney miRNA profiles were analyzed at 1.5, 6, 24, and 48 hours, revealing significant changes in expression associated with markers of septic AKI.
- Key findings include the identification of miR-762 as a newly elevated miRNA in the early phase and a significant downregulation of its target, Sar1b, alongside the downregulation of aquaporin-1, influenced by other identified miRNAs in the late phase.
Article Synopsis
- * Methods: NMRI mice underwent severe left renal ischemia-reperfusion injury or a sham operation, followed by Nx or sham one week later, with the assessment of several relevant markers for inflammation, oxidative stress, and fibrosis through RT-qPCR techniques.
- * Results: Nephrectomy helped the injured kidneys gradually regain function over 14 to 21 days, reducing inflammation and injury markers significantly, while without Nx, the kidneys showed increased inflammation and became completely fibrotic. This indicates Nx may slow the
(1) Background: Sepsis-induced acute kidney injury (AKI) is the most common form of acute kidney injury (AKI). We studied the temporal profile of the sepsis-induced renal proteome changes. (2) Methods: Male mice were injected intraperitoneally with bacterial lipopolysaccharide (LPS) or saline (control).
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