Publications by authors named "Beata Oroszova"
Article Synopsis
- A newly discovered bangle lectin (PHL) from the bacterium Photorhabdus asymbiotica primarily binds to fucose and may influence host-pathogen interactions and immune responses.
- PHL is a homo-dimer with multiple L-fucose binding sites, and various ligands, including calix[4]arenes and dendrimers, were tested for their effectiveness using a stable C-glycosidic bond.
- The dendrimers showed significantly higher binding affinity to PHL compared to free L-fucose, with crystal structures confirming that the ligands occupied most of PHL's binding sites.
The discovery of effective ligands for DC-SIGN receptor is one of the most challenging concepts of antiviral drug design due to the importance of this C-type lectin in infection processes. DC-SIGN recognizes mannosylated and fucosylated oligosaccharides but glycosidic linkages are accessible to both chemical and enzymatic degradations. To avoid this problem, the synthesis of stable glycoside mimetics has attracted increasing attention.
View Article and Find Full Text PDFThis work reports a modular and rapid approach to the stereoselective synthesis of a variety of α- and β-(1→2)-linked C-disaccharides. The key step is a Ni-catalyzed cross-coupling reaction of D-glucal pinacol boronate with alkyl halide glycoside easily prepared from commercially available D-glucal. The products of this sp(2) -sp(3) cross-coupling reaction can be converted to glucopyranosyl, mannopyranosyl, or 2-deoxy-glucopyranosyl C-mannopyranosides by one- or two-step stereoselective oxidative-reductive transformations.
View Article and Find Full Text PDF