Publications by authors named "Beata Judzinska"
Article Synopsis
- In Europe, rodent studies are the main method used to assess neurotoxicity, but they are expensive and raise ethical concerns, leading many to seek alternatives.
- There is a growing public demand for safer chemicals, as many on the market haven't been thoroughly tested for neurotoxic effects, prompting research into New Approach Methods (NAMs) to replace animal testing.
- The European Partnership for the Assessment of Risks from Chemicals (PARC) is working on NAMs to evaluate neurotoxicity, aiming to create faster and cheaper testing methods that can help regulatory agencies and industries improve safety assessments.
Drug discovery is a challenging process, with many compounds failing to progress due to unmet pharmacokinetic criteria. Lipophilicity is an important physicochemical parameter that affects various pharmacokinetic processes, including absorption, metabolism, and excretion. This study evaluated the lipophilic properties of a library of ipsapirone derivatives that were previously synthesized to affect dopamine and serotonin receptors.
View Article and Find Full Text PDFManufactured nanomaterials (NMs) are increasingly used in a wide range of industrial applications leading to a constant increase in the market size of nano-enabled products. The increased production and use of NMs are raising concerns among different stakeholder groups with regard to their effects on human and environmental health. Currently, nanosafety hazard assessment is still widely performed using in vivo (animal) models, however the development of robust and regulatory relevant strategies is required to prioritize and/or reduce animal testing.
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