Development of sampling method and chromatographic analysis of volatile organic compounds emitted from human skin.

Aim: The studies on volatile organic compounds emitted from skin are an interest for chemists, biologists and physicians due to their role in development of different scientific areas, including medical diagnostics, forensic medicine and the perfume design. This paper presents a proposal of two sampling methods applied to skin odor collection: the first one uses a bag of cellulose film, the second one, using cellulose sachets filled with active carbon.

Materials & Methods: Volatile organic compounds were adsorbed on carbon sorbent, removed via thermal desorption and analyzed using gas chromatograph with mass spectrometer.

Detection of potential chronic kidney disease markers in breath using gas chromatography with mass-spectral detection coupled with thermal desorption method.

The analytical potential of chromatographic breath analysis towards detection of compounds suggested as markers of chronic kidney disease (CKD) was tested. Until now, trimethylamine (TMA) considered as a potential marker of renal disorder was detected mainly in plasma. Detection of TMA in breath was rarely undertaken due to analytical difficulties associated with amines' properties.

[New opportunities of renal diseases diagnostics using gas chromatography].

During the last decade the amount of patients suffering from chronic kidney disease (CKD) has increased. The physicians' efforts are focused on early CKD diagnosis and reduction of the end-stage renal diseases incidence. The breath test seems to be a promising diagnostic device offering early noninvasive diseases detection.