[Risk factors and clinical characteristic patients with vulvar cancer].

Introduction: Vulvar cancer is very rare, accounting for about 3-5% female tract malignancies. Venereal diseases and cigarette smoking have been associated with vulvar cancer. Recently p53 gene mutation and Human Papilloma Virus (HPV) infections have been considered etiologic factors.

[Compliance endogenous and exogenous estriol in clinical practice].

The aim of this study is presenting contemporary datas of the chemical structure, clinical meanings and the role of the weakest estrogen-estriol. Measurement of the level of estriol can serve as a marker of fetus's well-being, can detect some congenital diseases like: Down syndrome, trisomy 18. Inappropriate values of E3 are often associated with high risk pregnancies like: pregnancy-induced hypertension, miscarriage, preterm delivery or intrahepatic cholestasis.

[Can vulvar carcinoma be a danger in the 21st century?].

Vulvar carcinoma accounts for 3-5% of all genital cancers. The most common histology of vulvar cancer is squamous cell carcinoma. It has been suggested that vulvar cancer exists as two separate diseases--HPV-positive, occurring in young women, and p53-positive, that occurs in older women.