Bisphosphonate effectiveness in patients with cirrhosis: An emulated clinical trial.

Background: Falls and fractures are common and morbid for patients with cirrhosis. Bisphosphonates are recommended for the prevention of fractures for people with osteoporosis cirrhosis; however, data supporting effectiveness in cirrhosis are lacking.

Aim: We sought to emulate a clinical trial of bisphosphonates in cirrhosis.

The RELAX randomized controlled trial: Stretching versus meditation for nocturnal muscle cramps.

Background: Muscle cramps are common among persons with cirrhosis and are associated with poor health-related quality of life (HRQOL). Treatment options are limited. We compared stretching or meditation in a randomized-controlled trial (RCT).

Neurocognitive and Muscular Capacities Are Associated with Frailty in Adults with Cirrhosis.

Background: Frailty is common in cirrhosis and associated with mortality, hospitalization, and reduced quality of life. Interventions aimed at forestalling frailty are limited by a lack of understanding of underlying physiologic deficits.

Aims: This study's aim was to examine contributions of discrete sensorimotor and neurocognitive capacities to conventional frailty measures of unipedal stance time, chair stands, and grip strength.