Publications by authors named "Bean-Bu Kang"
Chronic insulin resistance suppresses muscle and liver response to insulin, which is partially due to impaired vesicle trafficking. We report here that a formula consisting of resveratrol, ferulic acid and epigallocatechin-3--gallate is more effective in ameliorating muscle and hepatic insulin resistance than the anti-diabetic drugs, metformin and AICAR. The formula enhanced glucose transporter-4 (GLUT4) translocation to the plasma membrane in the insulin-resistant muscle cells by regulating both insulin-independent (calcium and AMPK) and insulin-dependent (PI3K) signaling molecules.
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- Dysregulation of vesicle trafficking in muscle contributes to insulin resistance, and this study examines how ferulic acid (FER) and resveratrol (RSV), both known for their ability to lower blood sugar, affect glucose utilization in insulin-resistant muscle cells.
- Using a model of insulin resistance induced by palmitate in L6 myotubes, the study found that both FER and RSV increased glucose uptake and glycogen synthesis in these cells.
- Mechanistic investigations revealed that FER enhances endosomal activities through a specific signaling pathway, while RSV promotes glucose transporter trafficking via a different pathway, suggesting they work through distinct but complementary routes to improve glucose transport in insulin-resistant muscle.
Osteopontin (OPN) is a secreted glycoprotein produced by osteoclasts, macrophages, T cells, hematopoietic cells, and vascular smooth muscle cells. It contributes to macrophage homing and cellular immunity. It also mediates neovascularization, inhibits apoptosis, and plays important roles in extracellular matrix remodeling and angiogenesis.
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