Publications by authors named "Bea Bosch"
Article Synopsis
- - Blood-based biomarkers, tested in a prospective real-world memory clinic cohort, show promise for evaluating cognitive impairment, with five specific plasma biomarkers being analyzed for diagnostic performance and applicability in clinical settings.
- - Among the 349 participants, plasma p-tau181 and GFAP were highly effective in distinguishing Alzheimer's disease from non-neurodegenerative conditions, achieving diagnostic accuracies of 94% and 92%, respectively.
- - The study found that p-tau181 not only predicted amyloid status with 85% accuracy but also worked well with NfL to identify frontotemporal dementia, highlighting the potential of these biomarkers in everyday clinical practice.
Article Synopsis
- Early- and late-onset Alzheimer's disease (EOAD and LOAD) share similar brain pathology but differ in cognitive profiles, with EOAD showing greater deficits in visual, motor, and executive functions.
- In a study of 195 individuals, the research found that EOAD patients experience a faster cognitive decline compared to those with LOAD, particularly in non-memory tasks, influenced by factors like education and APOE ε4 status.
- The findings suggest that age of onset significantly impacts cognitive deterioration, with younger patients facing a steeper decline in non-memory areas, while education level and genetic factors also play crucial roles in cognitive performance.
In this study functional magnetic resonance imaging (fMRI) is used to investigate the functional brain activation pattern in the preclinical stage of AD (pre-AD) subjects during a visual encoding memory task. Thirty subjects, eleven in the pre-AD stage, with decreased cerebrospinal fluid levels of Aβ42 (<500 pg/ml), and 19 controls with normal Aβ42 levels (CTR) were included. fMRI was acquired during a visual encoding task.
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