Distinct signaling pathways after higher or lower doses of radiation in three closely related human lymphoblast cell lines.

Purpose: The tumor suppressor p53 plays an essential role in cellular responses to DNA damage caused by ionizing radiation; therefore, this study aims to further explore the role that p53 plays at different doses of radiation.

Materials And Methods: The global cellular responses to higher-dose (10 Gy) and lower dose (iso-survival dose, i.e.