Publications by authors named "Bch Hwang"
Chemical and Cellular Formation of Reactive Oxygen Species from Secondary Organic Aerosols in Epithelial Lining Fluid.
Res Rep Health Eff Inst
December 2023
Article Synopsis
- Oxidative stress from reactive oxygen species (ROS) due to secondary organic aerosols (SOA) is linked to health issues, specifically from inhaled particulate matter (PM) less than 2.5 µm in diameter.
- The study aimed to analyze how ROS is created in the respiratory system, focusing on the role of chemical reactions and immune cells (macrophages) in this process.
- Using various experimental methods, including EPR spectroscopy and cellular assays, the researchers measured ROS formation and its impact on cell membranes, highlighting the significant contribution of biogenic SOA to superoxide radical generation.
Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often associated with soot particles coated by organic compounds, is a known carcinogen and mutagen. When mixed with organics, the kinetics and mechanisms of chemical transformations of BaP by ozone in indoor and outdoor environments are still not fully elucidated. Using direct analysis in real-time mass spectrometry (DART-MS), kinetics studies of the ozonolysis of BaP in thin films exhibited fast initial loss of BaP followed by a slower decay at long exposure times.
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