[Paraneoplastic acrokeratosis].

The authors discuss the main features of paraneoplastic acro keratosis, a new cutaneous marker of malignancy. Clinically, the condition begins at the extremities of the limbs and spreads upwards secondarily. The eruption is psoriasis-like squamous erythema of the face, hands and feet.

Acrokeratosis paraneoplastica--a new cutaneous marker of malignancy.

The historical background and the main clinical features of a specific paraneoplastic dermatosis, acrokeratosis paraneoplastica, are reviewed. Typical features are erythematous scaly lesions on the extremities, ears and bridge of the nose, associated with a malignancy, most frequently in the laryngopharyngeal region.

[The association tretinoin-erythromycin base: a new topical treatment for acne. Results of a multicentric trial on 347 cases (authors transl)].

A multicentric trial involving ten dermatological departments was conducted to evaluate the efficacy and tollerance of ANTIBIO-ABEREL (an association of Tretinoin and Erythromycin base) in 347 patients with persistant acne. Complete healing or considerable improvement was obtained in 85% of cases. This new treatment was active against both inflammatory lesions (papules and pustules) and retentional elements (microcysts and open comedones).

[Leg ulcer. Vascular and thrombosis factors. Each responsibility of those factors? (author's transl)].

In this paper the authors try to specify the leg ulcers physiopathology. They have first studied the vascular deficits, and they are able to conclude that this deficit is not the only factor responsible for the thrombosis. They try to rediscover the factors which could lead to the thrombosis, on the created local conditions (circulatory slackening, cooling, ischemia), by using clinical and biological "check-ups" as well as an exploration of the clotting.

[Paraneoplastic acrokeratosis].

Paraneoplastic acrokeratosis is a distinctive dermatosis observed only in patients with either carcinoma of the upper respiratory and digestive tract or with metastatic lymphnodes in the cervical or mediastinal region. The characteristics of this dermatosis are: acral beginning, erythematous, squamous and hyperkeratotic plaques with centripedal spreading and healing only after successful treatment of the carcinoma. An allergic or toxic skin reaction to a substance formed by the tumor cells is discussed as causative agent.

[Dermatology and polyposis of the gastro-intestinal tract (author's transl)].

The authors study three rare syndromes which are characterized by the association of cutaneous manifestations with an intestinal polyposis: Gardner's syndrome, Peutz-Jeghers-Touraine's syndrome, Cronkhite-Canada's syndrome. The Gardner's syndrome is transmitted with an autosomal prevalence, and its vital prognosis remains very porr. It is characterized by the association of various cutaneous manifestations such as fibromas, freckles, etc.

[Immunodiffusion and immunoelectrophoretic techniques applied to psoriasis (author's transl)].

Serum and scales of skin obtained from normal and psoriatic subjects are tested and estimated by immune diffusion and immune electrophoresis technics. The authors relate technics to produce rabbit's antibodies towards psoriatic serums and extracts of skin. Results coroborate the quantitative modifications of immunoglobulins and show in addition the presence of multiple precipitations lines in the alpha and gamma regions.

[Dermatosis caused by bone graft material (author's transl)].

Cases of dermatosis caused by surgical implants are not infrequently observed. They are represented by many clinical forms. The pathology slides most often reveal a more or less dense dermal infiltration associated with signs of allergic angeitis.

[Vogt-Koyanagi-Harada disease. About two observations (author's transl)].

After a reminder of clinical symptoms and development of the V.-K.-H.

[Hereditary Sipple syndrome (author's transl)].

This entity, isolated by Gorlin, is characterized by the presence of cutaneous and mucous neuromas, facial disfiguration resembling acromegalia as well as morphological changes to the extremities similar to those produced by Marfan's disease. These factors are also associated with multiple endocrinological neoplasms type II of Sipple's syndrome. In other words, malignant tumors developing from thyroid "C" cells as well as from bilateral benign pheochromocytoma (neoplasias which derive from the A.