Gemcitabine and docetaxel for high-risk non-muscle-invasive bladder cancer: EuroGemDoce group results.

Objective: To evaluate the oncological efficacy and safety of sequential intravesical gemcitabine/docetaxel (Gem/Doce) therapy in a European cohort of patients with high-risk and very-high-risk non-muscle-invasive bladder cancer (NMIBC) after previous Bacillus Calmette-Guérin (BCG) treatment.

Materials And Methods: Data were retrospectively collected from 95 patients with NMIBC, treated with Gem/Doce at 12 European centres between 2021 and 2024. Patients previously treated with BCG who had completed a full induction course and received at least one follow-up evaluation were included.

Arthroscopic Repair of Rotator Cuff Tears in Older Adults: A Retrospective Case-Series Study.

Introduction: Rotator cuff tears (RCTs) are a common source of pain in the shoulder girdle. There is still debate about the optimal treatment for older adults with RCTs. In clinical practice, patients who do not respond well to non-surgical management may still be eligible for operative treatment.

Evaluation of Macro- and Micro-Geometry of Models Made of Photopolymer Resins Using the PolyJet Method.

Additive manufacturing (AM) techniques are among the fastest-growing technologies for producing even the most geometrically complex models. Unfortunately, the lack of development of metrology guidelines for these methods, related to dimensional and geometry accuracy and surface roughness, significantly limits the commercialization of finished products manufactured using these methods. This paper aims to evaluate the macro- and micro-geometry of models manufactured using the PolyJet method from three types of photopolymer resins: Digital ABS Plus, RGD 720, and Vero Clear.

Long-lasting negativity in the left motoric brain structures during word memory inhibition in the Think/No-Think paradigm.

In this study, we investigated the electrical brain responses in a high-density EEG array (64 electrodes) elicited specifically by the word memory cue in the Think/No-Think paradigm in 46 participants. In a first step, we corroborated previous findings demonstrating sustained and reduced brain electrical frontal and parietal late potentials elicited by memory cues following the No-Think (NT) instructions as compared to the Think (T) instructions. The topographical analysis revealed that such reduction was significant 1000 ms after memory cue onset and that it was long-lasting for 1000 ms.

Innovative Approaches to 3D Printing of PA12 Forearm Orthoses: A Comprehensive Analysis of Mechanical Properties and Production Efficiency.

This research paper aims to explore the mechanical characteristics of polyamide PA12 (PA12) as a 3D material printed utilizing Selective Laser Sintering (SLS) and HP MultiJet Fusion (HP MJF) technologies in order to design and manufacture forearm orthoses. The study assessed the flowability of the materials used and compared the mechanical performance of PA12 with each other using tensile, flexure, and impact tests in five different fabrication orientations: X, Y, Z, tilted 45° XZ, and tilted 45° YZ. The results of the study provide, firstly-the data for testing the quality of the applied polyamide powder blend and, secondly-the data for the design of the orthosis geometry from the aspect of its strength parameters and the safety of construction.

Multi-modal analysis of infant cry types characterization: Acoustics, body language and brain signals.

Background: Infant crying is the first attempt babies use to communicate during their initial months of life. A misunderstanding of the cry message can compromise infant care and future neurodevelopmental process.

Methods: An exploratory study collecting multimodal data (i.

How can cry acoustics associate newborns' distress levels with neurophysiological and behavioral signals?

Introduction: Even though infant crying is a common phenomenon in humans' early life, it is still a challenge for researchers to properly understand it as a reflection of complex neurophysiological functions. Our study aims to determine the association between neonatal cry acoustics with neurophysiological signals and behavioral features according to different cry distress levels of newborns.

Methods: Multimodal data from 25 healthy term newborns were collected simultaneously recording infant cry vocalizations, electroencephalography (EEG), near-infrared spectroscopy (NIRS) and videos of facial expressions and body movements.

Developing psychoanalytic case conceptualization skills through didactic teaching: A randomized controlled trial.

Objective: Time-limited didactic interventions have been shown to be effective in developing "generic" case conceptualization skills. The objective of this study is to test whether similar interventions can be used to develop case conceptualization skills that are "specific" to a treatment modality.

Method: University psychology students were randomized to a target ( = 62) or a control group ( = 62).

Running away from phonological ambiguity, we stumble upon our words: Laboratory induced slips show differences between highly and lowly defensive people.

Introduction: Freud proposed that slips of the tongue, including apparently simple ones, always have a sense and constitute « a half-success and a half-failure » compromise resulting from defensive mechanisms.

Material And Methods: A total of 55 subjects participated in a French adaptation of the or SLIP-technique including 32 "neutral" and 32 taboo spoonerisms and measures of defensiveness. In accordance with a psychoanalytical and empirically supported distinction, we considered two kinds of defenses: elaborative or primary process and inhibitory or secondary process defenses, which were operationalized with the GeoCat and the Phonological-Nothing (PN) WordList, respectively.

Influence of Antibacterial Coating and Mechanical and Chemical Treatment on the Surface Properties of PA12 Parts Manufactured with SLS and MJF Techniques in the Context of Medical Applications.

Additive manufacturing (AM) is a rapidly growing branch of manufacturing techniques used, among others, in the medical industry. New machines and materials and additional processing methods are improved or developed. Due to the dynamic development of post-processing and its relative novelty, it has not yet been widely described in the literature.

People solve rebuses unwittingly-Both forward and backward: Empirical evidence for the mental effectiveness of the signifier.

Introduction: Freud proposed that names of clinically salient objects or situations, such as for example a beetle () in Mr. E's panic attack, refer through their phonological word form, and not through their meaning, to etiologically important events-here, "" which summarizes the indecisiveness of Mr. E's mother concerning her marriage with Mr.

Modeling of Surface Topography after Milling with a Lens-Shaped End-Mill, Considering Runout.

The paper presents a method of forecasting the product surface topography after five-axis machining with a lens-shaped end-mill. Surface roughness is one of the key parameters considered when assessing the effectiveness of the machining process, especially in the aviation, automotive, tooling and medical equipment industries. The developed method, the first published, presented in the paper is based on the analytical equations of the trajectory of the cutting edge motion, on the basis of which the cutter action surface is generated.

Management of local recurrence after radical nephrectomy: surgical removal with or without systemic treatment is still the gold standard. Results from a multicenter international cohort.

Objective: To evaluate the survival outcomes of patients with local recurrence after radical nephrectomy (RN) and to test the effect of surgery, as monotherapy or in combination with systemic treatment, on cancer-specific mortality (CSM).

Methods: Patients with local recurrence after RN were abstracted from an international dataset. The primary outcome was CSM.

Active surveillance in renal tumors: Clinical and oncological outcomes.

Context: Some patients diagnosed with small renal solid masses or complex cystic lesions may benefit from active surveillance (AS) instead of immediate treatment.

Aims: Report our series of patients undergoing AS for small renal solid and complex cystic lesions, and compare growth rates and outcomes between both types of lesions.

Materials And Methods: A retrospective review AS database for renal lesions was conducted.

Determination of Selected Texture Features on a Single-Layer Grinding Wheel Active Surface for Tracking Their Changes as a Result of Wear.

Measurements of the active surface microgeometry of the grinding wheel by contact and optical methods are commonly used to obtain a cloud of points representing the surface of the examined tool. Parameters that can be determined on the basis of the above-mentioned measurements can be universal parameters, which are commonly used to assess the geometric structure of a surface or parameters taking into account specific properties of the grinding wheel active surface (GWAS) structure. This article proposes a methodology for determining the average level of binder, which allows the definition the cut-off level required to separate from the measurement data: (i) the areas representing grains, (ii) the areas of gumming up of the grinding wheel, and (iii) deep cavities in approximately the same places on the investigated grinding wheel, regardless of the degree of its wear.

Image-guided percutaneous cryoablation of unresectable sacrococcygeal chordoma: Feasibility and outcome in a selected group of patients with long term follow-up.

Background: Chordoma is a rare malignant tumor of the axial skeleton. Percutaneous cryoablation (PCA) is a minimally invasive technique that allows freezing of tumors under imaging control. The purpose of our retrospective study was to investigate the outcome of PCA in a selected cohort of patients with sacrococcygeal chordoma, with a minimum of 5 years follow-up.

Psychiatric Disabilities and Other Long-term Consequences of Childhood Bacterial Meningitis.

Background: Bacterial meningitis is known to cause hearing impairments and neurologic deficits; however, less is known regarding psychiatric disabilities. In this study, we assessed psychiatric disabilities and other long-term consequences of childhood bacterial meningitis.

Methods: From a previously validated dataset, we selected children having had bacterial meningitis.

Invasive management of renal cell carcinoma in von Hippel-Lindau disease.

Introduction: Patients affected by von Hippel-Lindau (VHL) disease experience an increased risk for bilateral, synchronous, and metachronous renal cell carcinoma (RCC). Oncologic and functional outcomes are the main goals in the management of renal masses. We present our protocol for patients with VHL disease-associated RCC alongside functional and oncologic results observed in our series.

Eyes Wide Shut: Primary Process Opens Up.

Freud was the first to invite his patients to lie down on a couch, facilitating the closing of the eyes. If the mere fact of closing the eyes favors access to unconscious materials, it should also favor primary process mentation. Primary process is an associative mode of thought based on superficial similarities including phonology, while secondary process mentation in language is primarily concerned with meaning.

Influence of Pore Networking and Electric Current Density on the Crack Pattern in Reinforced Concrete Test Due to Pressure Rust Layer at Early Ages of an Accelerated Corrosion Test.

Research on early stages of corrosion of steel bars caused by chloride penetration is relevant in improving the durability of reinforced concrete structures. Similarly, the formation and development of cracks induced in the surrounding concrete is also of great importance. This paper uses integration of the analytical models examined in the published literature, combined with experimental research in corrosion induced at the concrete/steel interface, in estimating the time-to-crack initiation of reinforced concrete subjected to corrosion.

Phonological Ambiguity Detection Outside of Consciousness and Its Defensive Avoidance.

Freud proposes that in unconscious processing, logical connections are also (heavily) based upon phonological similarities. Repressed concerns, for example, would also be expressed by way of phonologic ambiguity. In order to investigate a possible unconscious influence of phonological similarity, 31 participants were submitted to a tachistoscopic subliminal priming experiment, with prime and target presented at 1 ms.

Influence of the Loading Speed on the Ductility Properties of Corroded Reinforcing Bars in Concrete.

In this work 144 reinforcing bars of high-ductility steel named B500SD were subjected to an accelerated corrosion treatment and then tested under tension at different loading speeds in order to assess the effect of corrosion on the ductility properties of the rebars. Results showed that the bars with a corrosion level as low as the one reducing the steel mass by 1% gave rise to a significant degradation on the ductility properties when a high loading speed was applied in tensile tests. In that case, the equivalent steel concept is useful to reduce the destabilising effect.