Publications by authors named "Bazaeva E"
Purpose: To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia.
Methods: An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57).
Results: Both medications effectively lowered blood pressure (BP) in both groups.
Article Synopsis
- - The study examined the relationship between high-density lipoprotein cholesterol (HDL-C) levels and gene expression in white blood cells from 38 men without coronary atherosclerosis, focusing on 63 specific genes involved in HDL metabolism and atherogenesis.
- - Results showed that certain genes related to HDL metabolism had varying correlations with HDL-C; some showed a negative correlation, while the APOA1 gene was positively correlated, suggesting complex regulation of cholesterol movement in the body.
- - The findings indicate that lower expression of inflammation-related genes is linked to higher HDL-C levels, and the study suggests that focusing on specific genes can help validate HDL function and its role in atherogenesis in patients without visible heart disease.
Article Synopsis
- The study investigates the differences in high-density lipoprotein (HDL) and its relationship with cholesterol levels in male subjects free of atherosclerosis, focusing on the roles of apoA-I and various lipid levels.
- It finds that individuals with lower HDL (hypoalphalipoproteinemia) have less apoA-I in their preβ-HDL, and the preβ-to-α ratio of apoA-I remains stable across certain HDL cholesterol ranges but increases with higher triacylglycerol levels.
- Additionally, gene expression analysis reveals that certain HDL metabolism-related genes are downregulated in people with higher HDL levels (hyperalphalipoproteinemia), which may lead to reduced cholesterol transport to the liver and
Objective: To assess the effect of moxonidine on bone metabolism and bone mineral density (BMD) in postmenopausal patients with arterial hypertension (AH) and osteopenia.
Materials And Methods: A randomized, open, clinical trial included 114 postmenopausal patients with AH. All participants were evaluated bone metabolism), BMD, telomerase activity (TA).
Purpose Of The Study: The study of the diagnostic value of biochemical markers of myocardial stress and inflammation in chronic heart failure (CHF) with different values of the ejection fraction (EF) of the left ventricle (LV).
Material And Methods: The cross-sectional study included 105 patients aged 24 to 84 years (mean 58+/-14 years) with stable chronic heart failure I-II NYHA functional class classification. The causes of CHF were ischemic heart disease (IHD) in 33% of patients and arterial hypertension (AH) - 67%.
Aim: To estimate effectiveness and safety of losartan and its combination with amlodipine in therapy of arterial hypertension.
Materials And Methods: The study based at 6 clinical centres was conducted in two stages. All 160 patients with grade I-II AH (103 women and 57 men aged 54 ± 12 yr) participated in stage 1 of the study and patients of centre No 1 (n = 100) in stage 2.