Transthyretin amyloid cardiomyopathy among patients hospitalized for heart failure and performance of an adapted wild-type ATTR-CM machine learning model: Findings from GWTG-HF.

Background: An 11-factor random forest model has been developed among ambulatory heart failure (HF) patients for identifying potential wild-type amyloidogenic TTR cardiomyopathy (wtATTR-CM). The model has not been evaluated in a large sample of patients hospitalized for HF.

Methods: This study included Medicare beneficiaries aged ≥65 years hospitalized for HF in the Get With The Guidelines-HF® Registry from 2008-2019.

Methods to determine the radiated power in SPI-mitigated disruptions in JET.

This paper presents techniques for evaluating the radiated power in JET disruptions. Disrupting plasmas are shown to have non-axisymmetric radiation profiles, motivating the re-evaluation of the standard techniques for calculating the total radiated power at JET using bolometry. Four single-channel bolometers at different toroidal locations are exploited to quantify the radiation asymmetry.

Design of a digital holography system for PFC erosion measurements on Proto-MPEX.

A project has been started at ORNL to develop a dual-wavelength digital holography system for plasma facing component erosion measurements on prototype material plasma exposure experiment. Such a system will allow in situ real-time measurements of component erosion. Initially the system will be developed with one laser, and first experimental laboratory measurements will be made with the single laser system.

High-speed digital holography for neutral gas and electron density imaging.

An instrument was developed using digital holographic reconstruction of the wavefront from a CO2 laser imaged on a high-speed commercial IR camera. An acousto-optic modulator is used to generate 1-25 μs pulses from a continuous-wave CO2 laser, both to limit the average power at the detector and also to freeze motion from sub-interframe time scales. Extensive effort was made to characterize and eliminate noise from vibrations and second-surface reflections.

Fast imaging of intact and shattered cryogenic neon pellets.

Compact condensed-matter injection technologies are increasingly used in magnetic fusion. One recent application is in disruption mitigation. An imaging system with less-than-100-µm- and sub-µs-resolution is described and used to characterize intact and shattered cryogenic neon pellets.

Digital holography for in situ real-time measurement of plasma-facing-component erosion.

In situ, real time measurement of net plasma-facing-component (PFC) erosion/deposition in a real plasma device is challenging due to the need for good spatial and temporal resolution, sufficient sensitivity, and immunity to fringe-jump errors. Design of a high-sensitivity, potentially high-speed, dual-wavelength CO2 laser digital holography system (nominally immune to fringe jumps) for PFC erosion measurement is discussed.

Reduction of edge-localized mode intensity using high-repetition-rate pellet injection in tokamak H-mode plasmas.

High repetition rate injection of deuterium pellets from the low-field side (LFS) of the DIII-D tokamak is shown to trigger high-frequency edge-localized modes (ELMs) at up to 12× the low natural ELM frequency in H-mode deuterium plasmas designed to match the ITER baseline configuration in shape, normalized beta, and input power just above the H-mode threshold. The pellet size, velocity, and injection location were chosen to limit penetration to the outer 10% of the plasma. The resulting perturbations to the plasma density and energy confinement time are thus minimal (<10%).

High speed digital holography for density and fluctuation measurements (invited).

The state of the art in electro-optics has advanced to the point where digital holographic acquisition of wavefronts is now possible. Holographic wavefront acquisition provides the phase of the wavefront at every measurement point. This can be done with accuracy on the order of a thousandth of a wavelength, given that there is sufficient care in the design of the system.

A compact flexible pellet injector for the TJ-II stellarator.

A compact pellet injector is being built for the TJ-II stellarator. It is an upgraded version of the "pellet injector in a suitcase" developed at Oak Ridge National Laboratory and installed on the Madison Symmetric Torus where it continues to be used in many plasma experiments. The design aim is to provide maximum flexibility at minimal cost, while allowing for future upgrades.

Effect of parallel flows and toroidicity on cross-field transport of pellet ablation matter in tokamak plasmas.

The first complete set of time-dependent equations describing the cross-field drift of ionized pellet ablation matter in tokamak plasma caused by polarization in the nonuniform magnetic field has been developed and solved numerically. Important new features impacting the drift dynamics have been identified, including the effect of pressure profile variations in the tokamak plasma, curvature drive by near-sonic field-aligned (parallel) flows, and the rotational transform of the magnetic field lines, and are considered from the viewpoint of the parallel vorticity equation. These new features are necessary to obtain favorable quantitative agreement between theory and experimental fuel deposition profiles for both inner and outer wall launched pellet injection cases on the DIII-D tokamak.

Resting thyroid and leptin hormone changes in women following intense, prolonged exercise training.

This study examined whether free (f) triidothyronine (T3), f thyroxine (T4), thyroid stimulating hormone (TSH), and leptin concentrations at rest changed in response to 20 weeks of exercise-training. Two groups of women were recruited for participation in the study, collegiate athletes ( n=17) and sedentary controls (n=4). Exercise training consisted of daily athletic activity such as rowing, running, and weight lifting.

Clathrin exchange during clathrin-mediated endocytosis.

During clathrin-mediated endocytosis, clathrin-coated pits invaginate to form clathrin-coated vesicles (CVs). Since clathrin-coated pits are planar structures, whereas CVs are spherical, there must be a structural rearrangement of clathrin as invagination occurs. This could occur through simple addition of clathrin triskelions to the edges of growing clathrin-coated pits with very little exchange occurring between clathrin in the pits and free clathrin in the cytosol, or it could occur through large scale exchange of free and bound clathrin.

Investigations of H-mode plasmas triggered directly by pellet injection in the DIII-D tokamak.

The transition from low-confinement (L-mode) to high-confinement (H-mode) plasmas has been directly produced by injecting frozen deuterium pellets in the DIII-D tokamak. H-mode transitions were produced at edge electron and ion temperatures below the L-mode values. This implies that a critical edge temperature is not necessary for H-mode transitions.

Experimental confirmation of impurity convection driven by the ion-temperature gradient in toroidal plasmas.

Strong, outward convection of low- Z impurity ions has been observed in DIII-D plasmas which have reduced anomalous transport, a weak density gradient, and a strong ion-temperature gradient. Comparing the measurements with theoretical predictions of collisional (neoclassical) transport indicates that the observed outward convection results from an effect known as "temperature screening." Taking into account the non-negligible effect of anomalous transport, quantitative agreement is found between the measured transport properties and the predicted values, including the strong Z dependence.

Reduced gastric acid inhibitory effect of a pGIP(1-30)NH2 fragment with potent pancreatic amylase inhibitory activity.

Gastric inhibitory polypeptide (GIP) strongly stimulates insulin secretion in the presence of glucose and also stimulates somatostatin release from gastric mucosa. It was reported recently that both stimulatory activities can be dissociated by removing the C-terminal 12 amino acid residues. Since insulin and somatostatin are involved in regulation of exocrine pancreatic and gastric secretion in rats, we compared the inhibitory effects of pGIP and the pGIP(1-30)NH2 fragment on pancreatic amylase and gastric acid secretion.

Structural requirements for galanin inhibition of pentagastrin-stimulated gastric acid secretion in conscious rats.

The effects of rat galanin, together with a number of its N- and C-terminal fragments, on pentagastrin-stimulated gastric acid secretion were studied in conscious rats equipped with chronic gastric fistulas. Similarly to its porcine counterpart studied previously, at a dose of 3 nmol/kg per h rat galanin was a potent inhibitor of gastric acid secretion. The N-terminal fragments, rat galanin-(1-10) and -(1-15), retained about 60% of the inhibitory potency of the whole galanin sequence whilst the C-terminal fragments, rat galanin-(2-29), -(3-29) and -(9-29), were unable to produce significant inhibition over comparable dose ranges.