Dual Anti-HER2 Therapy Vs Trastuzumab Alone with Neoadjuvant Anthracycline and Taxane in HER2-Positive Early-Stage Breast Cancer: Real-World Insights.

Introduction: The integration of anti-HER2 targeted therapy with chemotherapy has demonstrated an increase in pathologic complete response rates (pCR) in patients with HER2-positive early-stage breast cancer (EBC). This study presents real-world data on the use of trastuzumab with or without pertuzumab, in combination with anthracycline and taxanes-based chemotherapy regimen.

Methods: We conducted a retrospective analysis of patients with HER2-positive EBC who underwent neoadjuvant chemotherapy (NACT), treated between January 2014 and September 2021.

Radiology Report Annotation Using Generative Large Language Models: Comparative Analysis.

Recent advancements in large language models (LLMs), particularly GPT-3.5 and GPT-4, have sparked significant interest in their application within the medical field. This research offers a detailed comparative analysis of the abilities of GPT-3.

Evaluating GPT models for clinical note de-identification.

The rapid digitalization of healthcare has created a pressing need for solutions that manage clinical data securely while ensuring patient privacy. This study evaluates the capabilities of GPT-3.5 and GPT-4 models in de-identifying clinical notes and generating synthetic data, using API access and zero-shot prompt engineering to optimize computational efficiency.