Publications by authors named "Bayan A Alzumaili"
Malignant Epithelioid Mesenchymal Neoplasm with FUS::CREM Gene Fusion Arising in the Tongue: A Case Report Detailing Clinicopathological, Imaging, and Molecular Features.
Head Neck Pathol
August 2024
FUS::CREM fusion is a distinct primary driver in rare neoplasms of the head and neck and other anatomic sites. Herein, we describe the clinicopathological, imaging, and molecular features of a malignant epithelioid mesenchymal neoplasm harboring FUS::CREM fusion, arising in the tongue of a 46-year-old male. Clinically, the patient presented with a left upper neck mass.
View Article and Find Full Text PDFRAS p.Q61R is the most prevalent hot-spot mutation in RAS and RAS-like mutated thyroid nodules. A few studies evaluated RAS p.
View Article and Find Full Text PDFAlterations in Thyroid Carcinoma: A Novel Class of Primary Drivers with Significant Therapeutic Implications and Secondary Molecular Events Potentially Mediating Resistance in Thyroid Malignancy.
Thyroid
September 2024
Article Synopsis
- The study focuses on diagnosing thyroid cancer using tissue examination and molecular data, highlighting the specific genetic mutations associated with different types of thyroid malignancies, particularly papillary thyroid carcinoma.
- Researchers conducted a retrospective review of over 5,000 thyroid malignancies and identified 17 tumors with significant genetic alterations, with a special emphasis on the role of a specific gene family in cancer development.
- The findings suggest the existence of primary genetic drivers and secondary mutations in thyroid cancers, which could contribute to tumor progression and treatment resistance, paving the way for potential targeted therapies.
Article Synopsis
- - This study examines a cohort of 319 cases diagnosed as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) from 2016 to 2022, revealing demographic and clinical characteristics, including a female-to-male ratio of 2.7:1 and a mean age of 52 years.
- - Cytological analysis showed various findings from fine needle aspirations (FNA), with 49% of cases classified as atypia of undetermined significance, and significant molecular alterations were observed in 93% of patients.
- - Surgical outcomes indicated that 66% of the NIFTP-only cases were identified after hemithyroidectomy, with certain factors like FNA Bethesda category influencing the
Pediatric thyroid carcinomas (TCs) are rare and mainly approached based on data extrapolated from adults. We retrospectively reviewed 222 pediatric TCs (patient age less than or equal to 21 y). Lymph node (LN) disease volume at presentation was considered high if the largest positive LN measured ≥1 cm and/or >5 LNs were positive.
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