Serum amyloid A increases following routine vaccination of healthy adult horses.

Objectives: To measure the effect of routine vaccination on serum amyloid A (SAA) concentration in apparently healthy horses. We hypothesized that routine vaccination would increase SAA in healthy horses.

Animals: 21 apparently healthy client-owned horses and 15 Kansas State University College of Veterinary Medicine-owned horses.

Becoming a neurosurgeon in France: A qualitative study from the trainees' perspective.

Introduction: The training of neurosurgeons is evolving in a world of socio-professional changes, including the technological revolution, administrative pressure on stakeholders, reduced working hours, geographical heterogeneity, generational changes, to name but a few.

Research Question: This qualitative study aimed to explore experiences and feedback of French neurosurgical trainees concerning their training.

Material And Methods: The grounded theory approach was used with 23 neurosurgical trainees' interviews.

Trauma and sporadic desmoid tumor development: An approach toward real incidence and aspects of causality.

Objectives: The development of desmoid tumors (DT) is associated with trauma, which is an aspect with medicolegal relevance. The objective of this study was to analyze the proportion and type of trauma (surgical, blunt/fracture, implants), its lag time, and mutations of the CTNNB1 gene in patients with sporadic DT.

Methods: We analyzed a prospectively kept database of 381 females and 171 males, median age at disease onset 37.

Results of a French pilot database of standard of care of chronic subdural hematoma.

Background: A registry of chronic subdural hematoma does not exist in France yet.

Objective: To present a monocentric pilot project of a French registry of surgical management of chronic subdural hematoma.

Method: A monocentric pseudonymized formal database was created.

Long-term surgical oncological and functional outcome of large petroclival and cerebellopontine angle epidermoid cysts: a multicenter study.

Cranial nerve (CN) disorders are the foremost symptoms in cerebellopontine angle (CPA) and petroclival area (PCA) epidermoid cysts (EC).The aim of this work was to  assess the long-term surgical results on CN function and tumor control in these patients. We performed a retrospective cohort study about 56 consecutive patients operated on for a CPA or PCA EC between January 2001 and July 2019 in six participating French cranial base referral centers.

1.1 J Yb:YAG picosecond laser at 1 kHz repetition rate.

We demonstrate the generation of 1.1 J pulses of picosecond duration at 1 kHz repetition rate (1.1 kW average power) from a diode-pumped chirped pulse amplification Yb:YAG laser.

Medication reconciliation in ambulatory oncology new patient clinics.

Medication Reconciliation (MedRec) is an essential part of safe medication management and plays a key role in ensuring patient safety. A variety of methods and a number of different healthcare disciplines can be involved in the MedRec process and the timing and location of conducting MedRec can vary. In an effort to streamline the process in ambulatory oncology new patient clinics, a pilot of an alternative approach was undertaken whereby pharmacists with advanced prescribing privileges completed MedRec with patients prior to their clinic visit.

Personal and psychosocial factors of burnout: A survey within the French neurosurgical community.

Object: The neurosurgical community is particularly exposed to burnout. The objectives of this study were to report the prevalence and associated factors of burnout within the French neurosurgical community using validated academic and psychologic scales.

Methods: A national survey was sent to 141 French residents and 432 neurosurgeons between April and July 2019.

Course of depressive symptoms in men and women: differential effects of social, psychological, behavioral and somatic predictors.

In this study, we aimed to identify the most important and sex-specific social, psychological, behavioral and somatic predictors of recurrent depressive symptoms. Data was obtained at two measurement points within five years by the Gutenberg Health Study (GHS). Out of N = 12,061 individuals, a sample of 877 (age 52.

Improving the Course of Depressive Symptoms After Inpatient Psychotherapy Using Adjunct Web-Based Self-Help: Follow-Up Results of a Randomized Controlled Trial.

Background: We recently showed in a randomized controlled trial that Web-based self-help as an adjunct improved the effectiveness of multimodal inpatient psychotherapy for depression.

Objective: The aims of this study were (1) to determine whether a Web-based self-help adjunctive to multimodal inpatient psychotherapeutic treatment could also improve the course of depressive symptoms and (2) to identify predictors of residual depressive symptoms at follow-up.

Methods: Overall, 229 patients were randomized either to the Web-based self-help intervention group (Deprexis) or an active control group (Web-based information about depression and depressive symptoms) in addition to multimodal inpatient psychotherapy.

Implementation of a Web-Based Work-Related Psychological Aftercare Program Into Clinical Routine: Results of a Longitudinal Observational Study.

Background: As inpatient medical rehabilitation serves to promote work ability, vocational reintegration is a crucial outcome. However, previous Web-based trials on coping with work-related stress have been limited to Web-based recruitment of study participants.

Objective: The aim of our study was to evaluate the implementation of an empirically supported transdiagnostic psychodynamic Web-based aftercare program GSA (Gesund und Stressfrei am Arbeitsplatz [Healthy and stress-less at the workplace])-Online plus into the clinical routine of inpatient medical rehabilitation, to identify characteristics of patients who have received the recommendation for GSA-Online plus, and to determine helpfulness of the intervention and satisfaction of the participants as well as improvement in quality of life and mental health status of the regular users of GSA-Online plus.

Data-Driven Prediction of the Therapeutic Window during Subthalamic Deep Brain Stimulation Surgery.

Background: Moving from awake surgery under local anesthesia to asleep surgery under general anesthesia will require to precisely predict the outcome of deep brain stimulation.

Objective: To propose a data-driven prediction of both the therapeutic effect and side effects of the surgery.

Methods: The retrospective intraoperative data from 30 patients operated on in the subthalamic nucleus were used to train an artificial neural network to predict the deep brain stimulation outcome.

Functional atlases for analysis of motor and neuropsychological outcomes after medial globus pallidus and subthalamic stimulation.

Anatomical atlases have been developed to improve the targeting of basal ganglia in deep brain stimulation. However, the sole anatomy cannot predict the functional outcome of this surgery. Deep brain stimulation is often a compromise between several functional outcomes: motor, fluency and neuropsychological outcomes in particular.

Noradrenaline up-regulates volume-regulated chloride current by PKA-independent cAMP/exchange protein activated by cAMP pathway in human atrial myocytes.

Background And Purpose: Adrenergic regulation of cell volume-regulated chloride current (I ) is species-dependent. The present study investigates the mechanism underlying adrenergic regulation of I in human atrial myocytes.

Experimental Approach: Conventional whole-cell patch voltage-clamp techniques were used to record membrane current in human atrial myocytes.

In situ 3-D temperature mapping of high average power cryogenic laser amplifiers.

Heat generation is a key obstacle to scaling high energy solid-state lasers to the multi-kilowatt average powers required for several key applications. We demonstrate an accurate, in situ, noninvasive optical technique to that makes three-dimensional (3-D) temperature maps within cryogenic amplifiers operating at high average power. The temperature is determined by analyzing the fluorescence spectra with a neural network function.

An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)/Soft Tissue and Bone Sarcoma Group (STBSG).

Desmoid-type fibromatosis is a rare and locally aggressive monoclonal, fibroblastic proliferation characterized by a variable and often unpredictable clinical course. Currently, there is no established or evidence-based treatment approach available for this disease. Therefore, in 2015 the European Desmoid Working Group published a position paper giving recommendations on the treatment of this intriguing disease.

Strategies to increase laser damage performance of TaO/SiO mirrors by modifications of the top layer design.

TaO/SiO high reflection (HR) interference coatings for λ∼1  μm offer superior performance at high irradiance conditions. However, these coatings are not good candidates for high peak power conditions in comparison to HfO/SiO multilayer stacks. Here we show that the modification of the top layers design of a quarter wave TaO/SiO high reflector leads to 4-5 fold increase in the laser damage fluence compared to a quarter wave (TaO/SiO) when tested at λ=1.

Improvement of Pyramidal Tract Side Effect Prediction Using a Data-Driven Method in Subthalamic Stimulation.

Objective: subthalamic nucleus deep brain stimulation (STN DBS) is limited by the occurrence of a pyramidal tract side effect (PTSE) induced by electrical activation of the pyramidal tract. Predictive models are needed to assist the surgeon during the electrode trajectory preplanning. The objective of the study was to compare two methods of PTSE prediction based on clinical assessment of PTSE induced by STN DBS in patients with Parkinson's disease.

1 J, 0.5 kHz repetition rate picosecond laser.

We report the demonstration of a diode-pumped chirped pulse amplification Yb:YAG laser that produces λ=1.03  μm pulses of up to 1.5 J energy compressible to sub-5 ps duration at a repetition rate of 500 Hz (750 W average power).

Image-guided preoperative prediction of pyramidal tract side effect in deep brain stimulation: proof of concept and application to the pyramidal tract side effect induced by pallidal stimulation.

Deep brain stimulation of the medial globus pallidus (GPm) is a surgical procedure for treating patients suffering from Parkinson's disease. Its therapeutic effect may be limited by the presence of pyramidal tract side effect (PTSE). PTSE is a contraction time-locked to the stimulation when the current spreading reaches the motor fibers of the pyramidal tract within the internal capsule.

Measurements and simulations of boron carbide as degrader material for proton therapy.

We report on test measurements using boron carbide (B4C) as degrader material in comparison with the conventional graphite, which is currently used in many proton therapy degraders. Boron carbide is a material of lower average atomic weight and higher density than graphite. Calculations predict that, compared to graphite, the use of boron carbide results in a lower emittance behind the degrader due to the shorter degrader length.