Publications by authors named "Baukje Dotinga"
Background: In preterm infants, intestinal hypoxia may partly contribute to the pathophysiology of necrotizing enterocolitis through changes in gene expression. Splanchnic hypoxia can be detected with monitoring of regional splanchnic oxygen saturation (rSO). Using a piglet model of asphyxia, we aimed to correlate changes in rSO to gene expression.
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- Birth asphyxia is a leading cause of mortality and disability in children globally, with long non-coding RNAs (lncRNAs) presenting potential targets for new treatments due to their regulatory functions.
- A study using piglets examined key lncRNAs involved in oxidative stress and related processes, dividing 42 newborn subjects across four experimental conditions including varying reoxygenation methods after hypoxia.
- Results showed that exposure to hypoxia significantly affected lncRNA transcription levels, suggesting that these molecules play a crucial role in the brain's response to damage from perinatal asphyxia and could lead to future therapeutic strategies.
Article Synopsis
- The study examines the impact of different oxygen levels on the intestines of preterm infants using a newborn piglet model.
- Reoxygenating piglets after global hypoxia improved splanchnic oxygenation, but using 100% oxygen increased the risk of hyperoxia in the intestine.
- The research highlights the importance of monitoring splanchnic oxygenation, as decreased variability could suggest intestinal injury, regardless of the reoxygenation method used.
Background: Near-infrared spectroscopy is used in the assessment of regional splanchnic oxygen saturation (rSO), but solid reference values are scarce. We aimed to establish reference values of rSO for preterm infants during the first week after birth, both crude and modeled based on predictors.
Methods: We included infants with gestational age (GA) <32 weeks and/or birth weight <1200 g.
Nutrient requirements of preterm neonates may be substantial, to support growth and maturation processes in the presence of challenging post-natal circumstances. This may be accompanied by substantial intestinal oxygen requirements. Preterm neonates may not be able to meet these oxygen requirements, due to a developmental delay in intestinal oxygenation regulation mechanisms.
View Article and Find Full Text PDFObjectives: Moderately and late preterm children (MLPs, 32.0-36.9 weeks gestational age) have a greater risk of poorer growth.
View Article and Find Full Text PDFObjective: To determine the association between longitudinal growth measures (height, weight, head circumference, and extent of catch-up growth) and neuropsychological functioning at 7 years in moderately and late preterm children.
Methods: This study was part of a prospective, community-based cohort study. Data on growth were obtained from records on routine assessments in well-child centers until age 4 years and in a research setting at 7 years.