Publications by authors named "Baukje Brattinga"
Background: Postoperative cognitive dysfunction (POCD) is a common complication in older patients with cancer and is associated with decreased quality of life and increased disability and mortality rates. Systemic inflammation resulting in neuroinflammation is considered important in the pathogenesis of POCD. The aim of this study was to explore the association between the early surgery-induced inflammatory response and POCD within 3 months after surgery in older cancer patients.
View Article and Find Full Text PDFArticle Synopsis
- Postoperative delirium (POD) is a serious complication affecting nearly 1 in 5 patients after noncardiac surgery, with various preoperative and perioperative factors influencing its risk.
- A comprehensive analysis included data from 21 studies with over 8,000 patients to identify which risk factors significantly contribute to the development of POD.
- Key risk factors for POD identified include older age, higher ASA status, low body mass index, history of delirium, preoperative cognitive impairment, and elevated C-reactive protein levels.
Objective: This study investigated the patterns, predictors, and survival of recurrent disease following esophageal cancer surgery.
Background: Survival of recurrent esophageal cancer is usually poor, with limited prospects of remission.
Methods: This nationwide cohort study included patients with distal esophageal and gastroesophageal junction adenocarcinoma and squamous cell carcinoma after curatively intended esophagectomy in 2007 to 2016 (follow-up until January 2020).
Introduction: Post-operative delirium (POD) is associated with increased morbidity and mortality rates in older patients. Neuroinflammation, the activation of the intrinsic immune system of the brain, seems to be one of the mechanisms behind the development of POD. The aim of this study was to explore the association between the perioperative inflammatory response and the development of POD in a cohort of older oncological patients in need for surgery.
View Article and Find Full Text PDFArticle Synopsis
- This study analyzed trends in the treatment and outcomes for patients with distal esophageal and gastro-esophageal junction cancers in the Netherlands from 2007 to 2016.
- It found that the use of transthoracic esophagectomy, neo-adjuvant treatments, and minimally invasive surgery significantly increased during this period.
- Postoperative results improved, with lower complication rates, higher success in tumor removal, better lymph node retrieval, and longer survival times for patients.
Oncologic surgery results in substantially higher morbidity and mortality rates in older patients compared to younger patients, yet little is known about the relation between the preoperative inflammatory state and postoperative outcome in the specific group of older cancer patients. The aim of this study was to examine whether preoperative inflammatory markers could be a predictor of overall survival in older patients undergoing elective surgery for a solid malignant tumor. Patients 65 years and older undergoing surgery for a solid malignant tumor were included in a prospective cohort study.
View Article and Find Full Text PDFCellular senescence is a complex process and is one of the key elements of ageing [...
View Article and Find Full Text PDF