Publications by authors named "Baudin E"

PtSe_{2} is a van der Waals material transitioning from an indirect band gap semiconductor to a semimetal with increasing thickness. Its absorption threshold has been conjectured to originate from interband indirect transitions. By quantitative comparison between broadband (0.

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We report an additional case of FUS::CREM-rearranged neoplasm, with a distinctive clinical presentation and phenotype, in order to expand the spectrum of these tumors and to underline the major issues they raise in diagnosis and classification. A 52-year male patient, with a remote history of seminoma, presented with multiple lung, pancreatic, and renal tumor nodules, containing large nests of medium-sized epithelioid, monomorphic, tumor cells, which did not express any epithelial marker, but expressed all neuroendocrine markers. S100 protein labeled sustentacular-like cells.

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Background: For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now permit randomized, controlled trials of shortened-duration, all-oral treatments for rifampin-resistant tuberculosis.

Methods: We conducted a phase 3, multinational, open-label, randomized, controlled noninferiority trial to compare standard therapy for treatment of fluoroquinolone-susceptible, rifampin-resistant tuberculosis with five 9-month oral regimens that included various combinations of bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C), and pyrazinamide (Z).

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Background: In settings with low pneumococcal conjugate vaccine (PCV) coverage, multi-age cohort mass campaigns could increase population immunity, and fractional dosing could increase affordability. We aimed to evaluate the effect of mass campaigns on nasopharyngeal pneumococcal carriage of Pneumosil (PCV10) in children aged 1-9 years in Niger.

Methods: In this three-arm, open-label, cluster-randomised trial, 63 clusters of one to four villages in Niger were randomly assigned (3:3:1) using block randomisation to receive campaigns consisting of a single full dose of a 10-valent PCV (Pneumosil), a single one-fifth dose of Pneumosil, or no campaign.

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The double inactivation of TP53 and RB1 is considered typical of neuroendocrine carcinomas (NECs) but is assumed to be rare in high-grade neuroendocrine tumors (NETs). The immunohistochemical determination of the p53 and Rb status has therefore been proposed as a diagnostic tool. We studied this status in a large series of high-grade neuroendocrine neoplasms, from multiple origins, in order to (a) assess the patterns observed in the different histopathological categories, (b) compare them between the various anatomic sites, and (c) evaluate their possible diagnostic relevance.

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• This Clinical Practice Guideline provides key recommendations for managing rare endocrine tumours. • Neuroendocrine neoplasms of different origins, parathyroid carcinoma and intrathyroid thymic neoplasms are included. • The guideline covers clinical imaging and pathological diagnosis, staging and risk assessment, treatment and follow-up.

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Purpose: Mitotane is the only approved treatment for metastatic adrenocortical carcinoma (ACC). Monitoring plasma levels is recommended, but its predictive value is insufficient.

Methods: This prospective study of the French ENDOCAN-COMETE network aimed to investigate the prognostic role of plasma mitotane levels pharmacokinetics and free or bound to lipoprotein fraction measurements during six consecutive months.

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Everolimus and peptide receptor radionuclide therapy (PRRT, Lu-DOTATATE) are 2 treatments recommended in guidelines for gastroenteropancreatic metastatic neuroendocrine tumors. However, the best treatment sequence remains unknown. We designed a retrospective multicenter study that included patients from the national prospective database of the Groupe d'Étude des Tumeurs Endocrines who had been treated using everolimus and PRRT between April 2004 and October 2022.

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Prospective data are lacking on early somatostatin analog (SSA) therapy in bronchopulmonary neuroendocrine tumors (BP-NETs; typical carcinoids and atypical carcinoids (TCs and ACs)). SPINET (EudraCT: 2015-004992-62; NCT02683941) was a phase III, double-blind study of lanreotide autogel/depot (LAN; 120 mg every 28 days) plus best supportive care (BSC) vs placebo plus BSC, with an optional open-label treatment phase (LAN plus BSC). Patients had metastatic/unresectable, somatostatin receptor (SSTR)-positive TCs or ACs.

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Background: No randomised controlled trial has ever been done in patients with metastatic phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested beneficial effects of sunitinib. We aimed to evaluate the safety and efficacy of sunitinib in patients with metastatic phaeochromocytomas and paragangliomas.

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Context: Germline CDKN1B variants predispose patients to multiple endocrine neoplasia type 4 (MEN4), a rare MEN1-like syndrome, with <100 reported cases since its discovery in 2006. Although CDKN1B mutations are frequently suggested to explain cases of genetically negative MEN1, the prevalence and phenotype of MEN4 patients is poorly known, and genetic counseling is unclear.

Objective: To evaluate the prevalence of MEN4 in MEN1-suspected patients and characterize the phenotype of MEN4 patients.

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Hypoparathyroidism is the most frequent complication in thyroid surgery. The aim of this study was to evaluate the impact of intraoperative parathyroid gland identification, using autofluorescence imaging, on the rate of post-operative (PO) hypoparathyroidism in thyroid cancer surgery. Patients undergoing total thyroidectomy with central neck dissection from 2018 to 2022 were included.

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We report a large series of 40 patients presenting EPAS1-mutated paraganglioma (PGL) in whom we investigated a cause underlying chronic hypoxia. Four patients suffered from hypoxaemic heart disease. In patients with available haemoglobin electrophoresis results, 59% presented with a haemoglobin disorder, including six with sickle cell disease, five with sickle cell trait and two with heterozygous haemoglobin C disease.

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Article Synopsis
  • Medullary thyroid cancer (MTC) often has mutations in the RET gene, and while selective RET inhibitors (RETi) are effective treatments, most patients eventually develop resistance to these drugs.
  • A study analyzed 46 MTC patients treated with RETi from 2018 to 2022, finding that 26 discontinued treatment due to progression, death, or toxicity; resistance mechanisms included mutations in RAS genes and others in 75% of cases, and specific RET mutations explained resistance in the remaining 25%.
  • The research revealed that patients' tumors became more aggressive after treatment, indicated by increased Ki 67-index levels and a more poorly differentiated histology, highlighting the need
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  • Recent clinical trials of new immune checkpoint protein-targeted antibodies failed to show significant results, primarily because patients weren't screened for target expression prior to treatment.* -
  • The study utilized advanced methods like flow cytometry and single-cell RNA sequencing to analyze immune checkpoint expression on T-cells from various primary tumors, revealing extensive variability among patients.* -
  • Results indicated that while CD4FoxP3 T-cells co-expressed both stimulatory and inhibitory checkpoints, the expression levels in CD8 T-cells were generally lower, suggesting a need for better-targeted therapies in future cancer immunotherapy trials.*
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Background: Treatment for fluoroquinolone-resistant multidrug-resistant/rifampicin-resistant tuberculosis (pre-XDR TB) often lasts longer than treatment for less resistant strains, yields worse efficacy results, and causes substantial toxicity. The newer anti-tuberculosis drugs, bedaquiline and delamanid, and repurposed drugs clofazimine and linezolid, show great promise for combination in shorter, less-toxic, and effective regimens. To date, there has been no randomized, internally and concurrently controlled trial of a shorter, all-oral regimen comprising these newer and repurposed drugs sufficiently powered to produce results for pre-XDR TB patients.

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  • Anaplastic thyroid carcinoma (ATC) is a rare and aggressive thyroid cancer, and a study analyzed survival rates using data from 360 patients across France diagnosed between 2010 and 2020.
  • The median overall survival (OS) for all patients was 6.8 months, with better outcomes for those with certain cancer stages and treatments: stage IVb patients had a median OS of 11.4 months, while multimodal treatments significantly improved survival.
  • Key factors that improved OS included better performance status (ECOG 0-1), earlier cancer stage (IVb), and using multimodal treatments, while pure ATC and a high neutrophil-to-lymphocyte ratio (NLR)
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The prognostic importance of and mutations and their relationship to clinicopathologic parameters and outcomes in medullary thyroid carcinoma (MTC) need to be clarified. A multicenter retrospective cohort study was performed utilizing data from 290 patients with MTC. The molecular profile was determined and associations were examined with clinicopathologic data and outcomes.

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Patients with metastatic medullary thyroid cancer (MTC) who progressed under tyrosine kinase inhibitors can benefit from an alkylating agent such as dacarbazine or temozolomide. We describe two patients with metastatic MTC who developed a hypermutant phenotype after alkylating agent treatment. This phenotype was characterized by a high tumor mutational burden (TMB) and a mutational signature indicative of alkylating agent mutagenesis (single-base substitution 11).

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  • The study investigates the impact of vascular invasion (lymphatic or venous) on the risk of recurrence in patients with low-risk papillary thyroid carcinoma (PTC).
  • It included 141 patients diagnosed between 2013 and 2019, showing that 20.6% had confirmed lymphovascular invasion.
  • Results indicated that patients with lymphovascular invasion had a higher rate of persistent/recurrent disease, particularly those not treated with radioactive iodine, suggesting the need for better risk assessment in PTC management.
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Background: Adjuvant treatment with mitotane is commonly used after resection of adrenocortical carcinoma; however, treatment remains controversial, particularly if risk of recurrence is not high. We aimed to assess the efficacy and safety of adjuvant mitotane compared with surveillance alone following complete tumour resection in patients with adrenocortical carcinoma considered to be at low to intermediate risk of recurrence.

Methods: ADIUVO was a multicentre, open-label, parallel, randomised, phase 3 trial done in 23 centres across seven countries.

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  • - A retrospective national study analyzed the safety and outcomes of surgery for patients with metastatic lung neuroendocrine tumors, including 155 patients, with 41 undergoing surgery and 114 not.
  • - The study found a low complication rate of 4.9% in the surgical group and no postoperative deaths, with significant symptom improvement (42.5%) compared to the nonoperative group (14.4%).
  • - Although overall survival wasn’t reached in the surgical group, the nonoperative group's median survival was 4.3 years; factors like performance status and number of metastatic sites were linked to survival, while surgery itself didn't significantly impact survival.
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Article Synopsis
  • Pheochromocytomas and paragangliomas are rare neuroendocrine tumors that arise in the adrenal glands and other locations, with malignancy marked by distant metastases.
  • About 40% of these tumors are inherited and may be linked to various hereditary syndromes, with management provided by specialized centers in France.
  • Diagnosis and treatment require a comprehensive approach considering clinical symptoms, hormonal levels, genetics, and imaging, with multidisciplinary interventions including surgery, radiotherapy, and targeted medical therapies like sunitinib and temozolomide.
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