Polyphenol-enriched fraction from a Chinese herbal compound granule protects against D-galactose-induced apoptosis and metabolic disorders in PC12 cells.

Objectives: To investigate the protective effects of polyphenol-enriched fraction (PEF) derived from a Chinese herbal compound granule (HCG) against D-galactose (DG) induced injury in PC12 cells, and to analyze the metabolic pathways related to PC12 cell proliferation and apoptosis through a hydrogen-nuclear magnetic resonance (H-NMR) metabonomic study.

Methods: The PEF was separated from HCG extraction and quantified by ultraviolet spectrophotometry following purification. DG-induced PC12 cells were treated with three different dosages of PEF.

Cognitive enhancement and neuroprotective effects of a traditional Chinese herbal compound medicine on Aβ1-42 induced Alzheimer's disease in rats.

Introduction: We aimed to explore the role of a novel traditional herbal compound medicine (HCM) in Alzheimer's disease (AD).

Material And Methods: 72 rats were randomized into control, AD, Donepezil and HCM groups. Injection of -amyloid peptide (A1-42) into the lateral ventricle was used to induce AD in rats.