Publications by authors named "Batra G"
Aim: Research studies with porcine acellular bladder matrix (PABM) showed integration of only small sized stamps in recipient bladders, however for clinical use in bladder augmentation significantly larger patches are needed. We hypothesised pre-vascularisation with omentum may be a step towards clinical translation.
Method: Eight domestic pigs were operated three times 8-10 weeks apart: 1-Implantation; PABM with recorded dimensions were sutured around a tissue expanding device, wrapped in omentum and sutured to the anterior abdominal wall.
Article Synopsis
- The EuroHeart project aims to establish standardized definitions for outcome measures in cardiovascular clinical studies to enhance the evaluation of medical interventions and care.
- A group of 82 experts formed five Working Groups to identify key outcome measures for various cardiovascular conditions, using a systematic review and consensus methods to define these measures.
- In total, 24 mandatory (Level 1) and 48 optional (Level 2) outcome measures were established across five cardiovascular disease areas, providing a foundation for improved research and patient care quality.
The rotational spectrum of diphenylsilane was investigated using chirped-pulse Fourier transform microwave spectroscopy in the frequency range of 2-8 GHz. The lowest energy structure of diphenylsilane has C point group symmetry with the C symmetry axis coinciding with the -inertial axis of the molecule. Through the assignment of the main isotopologue as well as singly substituted heavy-atom isotopologues, including C, Si, and Si, we were able to obtain a comprehensive gas-phase structure of diphenylsilane.
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- * A working group, including experts from the European Society of Cardiology, conducted a systematic review and reached consensus on mandatory (Level 1) and optional (Level 2) measures through a Delphi process.
- * The final catalogue includes five Level 1 and two Level 2 outcome measures, along with five additional monitoring outcomes, which will enhance research quality and improve heart failure care.
Article Synopsis
- The placenta's normal development is really important for a baby to grow healthy during pregnancy, but there's a problem called Delayed Villous Maturation (DVM) that can cause stillbirths.
- DVM happens when small structures in the placenta don't develop properly and are fewer in number, which can be linked to conditions like diabetes in mothers, but sometimes it just happens for no clear reason.
- Doctors can only find out if DVM is present after the baby is born by looking at tissues under a microscope, and this review talks about ways to better recognize DVM so that it can be distinguished from healthy placentas.
Article Synopsis
- Research shows that T cell responses to the SARS-CoV-2 spike protein were significantly boosted in vaccinated individuals after the omicron surge, suggesting many had asymptomatic infections.
- In a study of 216 individuals, those fully vaccinated with two doses exhibited T cell responses comparable to those who had recovered from COVID-19 or received booster shots, following exposure to omicron.
- The findings also revealed strong T cell reactivity against various omicron sub-variants, indicating that the immune system can effectively respond to new strains even after vaccination.
Aim: To investigate associations between psychosocial burden and biomarkers reflecting pathophysiological pathways in patients with chronic coronary syndrome.
Methods: Psychosocial (PS) factors were collected from self-assessed questionnaires and biomarkers representing inflammation (high-sensitivity [hs]-C-reactive protein [CRP], interleukin-6 [IL-6], lipoprotein-associated phospholipase A2 [Lp-PLA2]) and cardiac injury/stress (hs-troponin T [hs-TnT], N-terminal pro-B type natriuretic peptide [NT-proBNP]) were measured in 12,492 patients with chronic coronary syndrome in the STABILITY trial. Associations between level of each psychosocial factor (never-rarely (reference), sometimes, often-always) and biomarkers were evaluated using linear models with adjusted geometric mean ratios (GMR).
The recent astronomical observations of the simplest aromatic nitrile benzonitrile, -CHCN, followed by a five-membered and a bicyclic CN-functionalized ring in TMC-1 have provided a significant impetus to the field for searches of cyclic complex organic molecules in space. One such example is 2,4,6-cycloheptatriene-1-carbonitrile, a seven-membered ring with a -CN group attached to the sp-hybridized carbon atom. With a permanent electric dipole moment of 4.
View Article and Find Full Text PDFAims/hypothesis: Parenting a child with type 1 diabetes has been associated with stress-related symptoms. This study aimed to elucidate the potential impact on parental risk of major cardiovascular events (MCE) and death.
Methods: In this register-based study, we included the parents of 18,871 children, born 1987-2020 and diagnosed with type 1 diabetes in Sweden at <18 years.
Aims: The European Unified Registries On Heart Care Evaluation and Randomized Trials (EuroHeart) aims to improve the quality of care and clinical outcomes for patients with cardiovascular disease. The collaboration of acute coronary syndrome/percutaneous coronary intervention (ACS/PCI) registries is operational in seven vanguard European Society of Cardiology member countries.
Methods And Results: Adults admitted to hospitals with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) are included, and individual patient-level data collected and aligned according to the internationally agreed EuroHeart data standards for ACS/PCI.
Renal cell carcinomas are known for their unforeseeable metastatic pattern. They are known to have high metastatic potential, thus commonly associated with synchronous or metachronous metastatic presentation. At the time of diagnosis, approximately one-third of patients present with metastatic disease.
View Article and Find Full Text PDFBackground: Amiodarone is an established treatment for atrial fibrillation (AF) but might interfere with the metabolism of apixaban or warfarin. Therefore, the aim was to investigate the occurrence of major bleeding among patients with AF treated with amiodarone in combination with apixaban or warfarin.
Methods: Retrospective observational study using Swedish health registers.
Article Synopsis
- The study investigates how biomarker concentrations change during acute coronary syndrome (ACS) to provide insights into heart damage, stress, and inflammation.
- Researchers measured several biomarkers in nearly 17,000 ACS patients from the PLATO trial, finding that most biomarkers showed varying concentration patterns correlated with the time since symptoms began.
- Results indicated that biomarkers like hs-cTnT and hs-cTnI responded differently based on patients' sex, and emphasizes the importance of considering the time from symptom onset when analyzing these biomarker results in ACS.
Epilepsy is a prevalent neurological disorder characterized by neuronal hypersynchronous discharge in the brain, leading to central nervous system (CNS) dysfunction. Despite the availability of anti-epileptic drugs (AEDs), resistance to AEDs is the greatest challenge in treating epilepsy. The role of sphingosine-1-phosphate-receptor 1 (S1PR1) in drug-resistant epilepsy is unexplored.
View Article and Find Full Text PDFAim: To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment.
Methods: All patients in Sweden undergoing valvular intervention with AF were included. Associations between OAC exposure and cardiovascular (CV) events (composite of CV death, ischaemic stroke or systemic embolism) and major bleeding were investigated using Cox regression analysis.
European Society of Cardiology quality indicators for the care and outcomes of adults undergoing transcatheter aortic valve implantation.
Eur Heart J Qual Care Clin Outcomes
December 2024
Aims: To develop a suite of quality indicators (QIs) for the evaluation of the care and outcomes for adults undergoing transcatheter aortic valve implantation (TAVI).
Methods And Results: We followed the European Society of Cardiology (ESC) methodology for the development of QIs. Key domains were identified by constructing a conceptual framework for the delivery of TAVI care.
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and is associated with dementia. Presently, various chemical and environmental agents are used to induce models of Alzheimer disease to investigate the efficacy of different therapeutic drugs. We screened literature from databases such as PubMed, ScienceDirect, and Google scholar, emphasizing the diverse targeting mechanisms of neuro degeneration explored in models.
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- The study investigates how factors like marriage style, education, and parenting affect depression in married individuals, as previous research shows that family and societal influences impact psychological well-being and life satisfaction.
- Involving 433 married participants from Istanbul, the research utilizes machine learning techniques—specifically decision trees (DT) and random forests (RF)—to predict depressive symptoms, achieving an 80% accuracy with DT and 60% with RF.
- The findings suggest that these machine learning models outperform traditional statistical methods in identifying couples at risk for depression, paving the way for better support systems to proactively address mental health in married individuals.
The interaction of water and polycyclic aromatic hydrocarbons is of fundamental importance in areas as diverse as materials science and atmospheric and interstellar chemistry. The interplay between hydrogen bonding and dipole-π interactions results in subtle dynamics that are challenging to describe from first principles. Here, we employ far-IR action vibrational spectroscopy with the infrared free-electron laser FELIX to investigate naphthalene with one to three water molecules.
View Article and Find Full Text PDFBackground: There are conflicting data on outcomes in patients with atrial fibrillation treated with non-vitamin K oral anticoagulants across varying body mass index (BMI). We investigated cardiovascular and bleeding risk in patients with atrial fibrillation with varying BMI.
Methods And Results: Observational cohort study from the Swedish oral anticoagulation registry between August 2, 2011, and December 31, 2018.
Article Synopsis
- Autism Spectrum Disorder (ASD) is a complex condition, and current animal models like Valproic Acid (VPA) and Propionic Acid (PPA) were found to be inadequate in mimicking the human disease fully.
- The study tested several chemically induced animal models (including Poly I:C and Dioxin) to identify which best reflects the clinical features of ASD, with the Poly I:C model showing the closest resemblance.
- Findings indicated significant behavioral and developmental changes, increased oxidative stress, and altered gene expression related to ASD in the model groups, highlighting the role of maternal immune activation in influencing embryonic development and contributing to ASD.
Article Synopsis
- - This study aimed to explore how health-related quality of life (HRQoL) is linked to serious cardiovascular and cerebrovascular events (MACCE) in patients with ischaemic heart disease (IHD).
- - Researchers analyzed data from 51 studies involving over 134,000 participants and found that lower HRQoL scores are associated with a higher risk of MACCE and all-cause mortality.
- - The findings suggest that regularly assessing HRQoL could improve patient care by helping to identify individuals with IHD who may need targeted interventions to reduce their risk of adverse outcomes.
Background And Hypothesis: Schizophrenia and comorbid substance use disorders (SUDs) are associated with poor treatment outcomes but differences between the associations of different SUDs with clinical outcomes are poorly characterized. This study examines the associations of comorbid SUDs with clinical outcomes in schizophrenia using a largescale electronic health record (EHR) database.
Design: Real-world data (RWD) analysis using the NeuroBlu database; de-identified EHR data were analysed.
Article Synopsis
- Large-scale assessments of soil-transmitted helminth (STH) programs are critical for understanding the need for mass drug administration (MDA) in India; baseline surveys showed high prevalence rates of STHs in Chhattisgarh (80.2% in 2015) and Himachal Pradesh (29.0% in 2016).
- Follow-up surveys in 2018 revealed a dramatic drop in prevalence after multiple rounds of MDA, with Chhattisgarh showing an 85.5% reduction to 11.6% and Himachal Pradesh achieving a remarkable 99.0% reduction to 0.3%.
- The significant decrease in STH infections is attributed to the effectiveness of sustained de
Context.—: Chronic histiocytic intervillositis (CHI) is a rare condition characterized by maternal immune cell infiltration into the human placenta. CHI is strongly associated with fetal growth restriction, miscarriage, and stillbirth, and knowledge of its etiology, and consequently effective treatment, is limited.
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