Therapeutic Potential of Rare Sesterterpenoids from Aspergillus Variecolor Strain SDG and Docking Studies.

Ethyl acetate extract of the cultures of the soil-derived filamentous fungus, Aspergillus variecolor SDG strain from Nallamala forest resulted in the isolation of extremely rare sesterterpenoids, stellatic acid (1) and andilesin C (2). We report a thorough chemical characterization of these compounds using various spectroscopic techniques and evaluation of their in vitro preclinical therapeutic potential. Stellatic acid exhibits potent antioxidant activity with an IC of 38 μg/mL and significant anticancer activity against HeLa, HepG2, MCF7, and A549 cancer cell lines with an IC of 7-12 μM.

Silver Nanoparticles Induced Metabolic Perturbations in : Evaluation Using the UPLC-QTof-MS Platform.

Silver nanoparticles (AgNPs) have been widely utilized in various biomedical and antimicrobial technologies, displaying broad-spectrum activities against Gram-negative and Gram-positive bacteria including multidrug-resistant strains. However, the emergence of resistance to AgNPs upon repeated exposure and the survival of bacteria after initial exposure to antimicrobial agents pose a threat, as they may lead to the development of new resistant populations. To combat the early stages of antibacterial resistance, systematic analysis is essential to understand the immediate response of bacteria to antimicrobial agents.

Anti-inflammatory potential of 1--methyl chrysophanol from ICTA 103: an exploratory study.

The present study was designed to investigate the anti-inflammatory potential of producing 1--methyl chrysophanol (OMC), a member of the hydroxyanthraquinone family. The anti-inflammatory potential was evaluated initially through analysis against tumor necrosis factor- α and cyclooxygenase-2. The same activity was further confirmed based on the protein denaturation method as well as by a carrageenan-induced paw edema model in rats.

Aryl-n-hexanamide linked enaminones of usnic acid as promising antimicrobial agents.

Lichen secondary metabolites are well explored medicinal agents with diverse pharmacological properties. One of the important antibiotic lichen secondary metabolites is usnic acid. Its diverse medicinal profiles prompted us to explore it as a potential antitubercular molecule.

A review on hydroxy anthraquinones from bacteria: crosstalk's of structures and biological activities.

Anthraquinones (AQ), unveiling large structural diversity, among polyketides demonstrate a wide range of applications. The hydroxy anthraquinones (HAQ), a group of anthraquinone derivatives, are secondary metabolites produced by bacteria and eukaryotes. Plant-based HAQ are well-studied unlike bacterial HAQ and applied as herbal medicine for centuries.

A comprehensive review on α-D-Glucans: Structural and functional diversity, derivatization and bioapplications.

Glucans are the most abundant natural polysaccharides across the living kingdom with tremendous biological activities. Now a days, α-D-glucans are gaining importance as a prebiotics, nutraceuticals, immunostimulants, antiproliferative agents and biodegradable polymers in pharmaceutical and cosmetic sectors. A wide variety of bioresources including bacteria, fungi, lichens, algae, plants and animals produce α-D-glucans either as an exopolysaccharide (EPS) or a cell wall component or an energy storage polymer.

Mutanase Enzyme from RSP02: Characterization and Application as a Biocontrol Agent.

Mutanases are enzymes that have the ability to cleave α-1,3 linkages in glucan polymer. In the present investigation, mutanase enzyme purified from the culture filtrate of was evaluated for biofilm degradation and antimicrobial activity against pathogenic fungi along with enzyme kinetics, activation energies, pH and thermal stability. Biochemical and molecular characterization depicted that the enzyme showed optimum activity at pH 5.

Design and study of anticaries effect of different medicinal plants against S.mutans glucosyltransferase.

Background: The present study was aimed to evaluate the molecular level anticaries effect of different medicinal plants against Streptococcus mutans (S.mutans) glucosyltransferases (gtf).

Methods: A total of six natural sources named as Terminalia chebula (T.

Formulation and evaluation of transdermal drug delivery of topiramate.

Background: Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. Among the various types of transdermal patches, matrix dispersion type systems disperse the drug in the solvent along with the polymers and solvent is allowed to evaporate forming a homogeneous drug-polymer matrix. The objective of the present study was to design and formulate TDDS of topiramate (TPM) and to evaluate their extended release and .