Publications by authors named "Bastien Suire"
In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal the presence of the marine dinoflagellate Vulcanodinium rugosum and its associated cyclic imine toxins. Specifically, we show that the toxin PortimineA, strongly enriched in environmental samples, impedes ribosome function in human keratinocytes, which subsequently activates the stress kinases ZAKα and P38 and promotes the nucleation of the human NLRP1 inflammasome, leading to the release of IL-1β/IL-18 pro-inflammatory cytokines and cell death.
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- Scientists found that a specific part of our immune system, called the NLRP1 inflammasome, can detect a harmful substance called exotoxin A produced by a bacterium named Pseudomonas aeruginosa, which can cause chronic infections.
- This exotoxin attacks a protein in our cells, leading to stress and activating the NLRP1 inflammasome, which can cause further cell damage.
- In people with cystic fibrosis, the cells were more sensitive to this exotoxin, showing increased damage, but using certain inhibitors could help reduce this sensitivity.