Publications by authors named "Bastien Orsini"

Objectives: To evaluate the oncological efficacy and complications of cryoablation (CA) in treating lung metastases from colorectal cancer (CRC) at the lung periphery.

Materials And Methods: The inclusion criteria for this bicenter retrospective study included patients with histologically confirmed CRC, with radiologically confirmed lung metastases at the periphery of the lung (distance of less than or equal to 2 cm from the costal, diaphragmatic, or cervical pleura) treated with CA between January 2017 and June 2022. Patients with intra-parenchymal metastases or metastases close to the mediastinal pleura and patients without follow-up were excluded.

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Article Synopsis
  • - The study aimed to determine if using chlorhexidine gluconate (CHG) for oropharyngeal and nasopharyngeal decontamination could reduce respiratory complications following lung cancer surgery, similar to its effects observed in cardiac surgeries.
  • - In a trial with 474 lung cancer patients, 450 were analyzed after some withdrew consent, showing no significant difference in the need for postoperative mechanical ventilation or respiratory infections between those treated with CHG and those with a placebo.
  • - Although the CHG group had fewer cases of certain infections, like bacteremia and surgical-site infection, the trial found no substantial differences in overall health outcomes or hospital stays between the groups after surgery.
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Objectives: Thymectomy may be part of the therapeutic strategy in patients with myasthenia gravis (MG) without thymoma. Median sternotomy is still considered as the gold standard, but during the last 15 years, several groups have demonstrated the non-inferiority of cervicotomy with upper sternotomy and minimally invasive techniques. To date, there is no consensus on surgical procedure choice.

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Background: Video-assisted thoracoscopic surgery (VATS) lobectomy has recently become the recommended approach for stage I non-small cell lung cancer. However, these guidelines are not based on any large randomized control trial. Our study used propensity scores and a sensitivity analysis to compare VATS lobectomy with open thoracotomy.

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The aim of this study was to assess the evolution of survival in patients treated surgically for non-small cell lung cancer (NSCLC) between 2005 and 2012.From January 2005 to December 2012, 34 006 patients underwent pulmonary resection for NSCLC and were included in the French national database Epithor. Patients' characteristics, procedures and survival were analysed.

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  • This study investigates the use of an embedded device that measures endogenous fluorescence to differentiate between malignant lung lesions and healthy lung tissue in patients suspected of having non-small cell lung cancer (NSCLC).
  • The study involved 96 patients and found that the fluorescence intensity was significantly higher in NSCLC lesions compared to surrounding healthy tissue and non-tumoral lesions.
  • The findings suggest that the embedded device could help improve diagnostic accuracy for lung cancer, as it identified specific fluorescence characteristics (like photobleaching) that were more pronounced in malignant lesions.
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Objectives: The incidence rate of prolonged air leak (PAL) after lobectomy, defined as any air leak prolonged beyond 7 days, can be estimated to be in between 6 and 15%. In 2011, the Epithor group elaborated an accurate predictive score for PAL after open lung resections, so-called IPAL (index of prolonged air leak), from a nation-based surgical cohort constituted between 2004 and 2008. Since 2008, video-assisted thoracic surgery (VATS) has become popular in France among the thoracic surgical community, reaching almost 14% of lobectomies performed with this method in 2012.

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Background: Bronchial resection and reimplantation in surgical management of lung cancer is intended to spare lung parenchyma, with curative intent. We studied the incidence and management of anastomotic complications after such procedures.

Methods: We retrospectively reviewed charts of patients referred to our center for lung tumors who underwent bronchial resection and reimplantation from 1992 to 2011.

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  • The French organ transplantation authorities established the 'high-emergency waiting list' (HEWL) in 2007 to address the high mortality rate among patients on the regular waiting list for lung transplantation (LTx).
  • A study analyzing data from 101 HEWL patients showed that 95 received transplants, with a median wait time of 4 days, while 6 patients died before receiving LTx; the patients commonly suffered from conditions like cystic fibrosis and pulmonary fibrosis.
  • Despite the HEWL improving access to LTx for patients in respiratory distress, it also resulted in a higher risk of post-transplant mortality, with survival rates at one and three years being 67.5% and 59%, respectively.
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Clamshell incision with transverse sternotomy is the approach of choice for bilateral lung transplantation when cardiopulmonary bypass becomes necessary or to improve exposure. Sternal dehiscence is a well-known complication of this approach. This results in chronic thoracic pain and contributes to a delayed pulmonary rehabilitation.

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Objectives: Lung transplantation is the only life-saving treatment for end-stage respiratory disease. The outcome will depend on the graft quality, surgical conditions and recipient factors. Twinned single-lung transplantation defines as two different recipients treated with lung grafts from the same donor.

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We report a case of renal artery thrombosis resulting from a stent fracture in a patient with a solitary functional kidney. It was successfully revascularized by surgical repair despite renal ischemia lasting more than 48 hours. This article illustrates the danger of generalizing endovascular stenting in renal artery disease regardless of the etiology.

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Objective: To assess the potential benefit of the addition of a covered stent to a subintimal recanalized artery in patients with femoro-popliteal occlusions.

Methods: From September 2003 to October 2005, we retrospectively analyzed all patients admitted for severe claudication or critical limb ischemia related to long femoro-popliteal occlusions and treated with subintimal recanalization. Patients were divided into two groups depending on whether they received a stent or not.

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