Publications by authors named "Bastian Wobbe"
Safety of Naldemedine for Opioid-Induced Constipation - A Systematic Review and Meta-Analysis.
J Pain Palliat Care Pharmacother
December 2024
Naldemedine is a peripheral acting µ-opioid receptor antagonist approved by the Food and Drug Administration to treat opioid-induced constipation. Concerns about side effects like opioid withdrawal prevent its widespread use, especially for cancer patients. We performed this systematic review and meta-analysis to evaluate existing safety data of naldemedine treating opioid-induced constipation following the PRISMA guidelines.
View Article and Find Full Text PDFNaldemedine versus placebo in opioid-induced constipation: a meta-analysis.
BMJ Support Palliat Care
January 2024
Objective: Opioid-induced constipation (OIC) is a frequent adverse event among patients receiving chronic pain therapy that is requiring opioids. Naldemedine was approved by the Food and Drug Administration to treat OIC and appears to be more efficient than any other peripherally acting µ-opioid receptor antagonist. This meta-analysis aimed at assessing the available data on naldemedine in terms of efficacy.
View Article and Find Full Text PDFStudies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting.
View Article and Find Full Text PDFArticle Synopsis
- Adequate anticoagulation during catheter ablation for atrial fibrillation is essential to prevent serious bleeding and clot-related events.
- This updated meta-analysis evaluated the safety and effectiveness of uninterrupted and minimally interrupted direct oral anticoagulants (DOACs) compared to uninterrupted vitamin K antagonists (VKAs) in patients undergoing the procedure, based on 42 studies involving over 22,000 patients.
- The results indicated that patients on uninterrupted DOAC therapy experienced significantly lower major bleeding rates than those on VKAs, while both DOAC strategies proved effective in preventing strokes and transient ischemic attacks, making them preferable options for anticoagulation during the procedure.
Aim: To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.
Methods: A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31, 2017. The inclusion criteria were comparative, randomized controlled trials (RCTs) for deceased donor liver (DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin (UW) solution or histidine-tryptophan-ketoglutarate (HTK), Celsior (CS) and Institut Georges Lopez (IGL-1) solutions.