[Atraumatic splenic rupture in Legionella pneumonia].

A 48-year-old male patient was admitted to hospital with Legionella pneumonia. He developed a splenic rupture 1 day after admission, which was surgically treated. Retrospectively, the splenomegaly could already be seen by sonography on admission.

Benralizumab versus Mepolizumab for Eosinophilic Granulomatosis with Polyangiitis.

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a vasculitis characterized by eosinophilic inflammation. Benralizumab, a monoclonal antibody against the interleukin-5α receptor expressed on eosinophils, may be an option for treating EGPA.

Methods: We conducted a multicenter, double-blind, phase 3, randomized, active-controlled noninferiority trial to evaluate the efficacy and safety of benralizumab as compared with mepolizumab.

Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study.

Background: A double-blind, placebo-controlled, phase III study (200622) showed that mepolizumab reduces disease flares for patients with uncontrolled FIP1-like-1-platelet-derived growth factor receptor α-negative hypereosinophilic syndrome (HES) and two or more flares in the previous year.

Objective: To further characterize the safety, clinical benefit, and pharmacodynamics of mepolizumab.

Methods: Eligible patients from both treatment arms of the double-blind study could enter an open-label extension study (205203; NCT03306043) to receive 4-weekly mepolizumab (300 mg subcutaneously) plus background therapy for 20 weeks.

[Fever, skin changes, myalgia--from early symptom to diagnosis].

New clinical symptoms in the context of rheumatic inflammatory system diseases require the exact knowledge of the anamnestic symptom-characteristic. Fever, skin changes and myalgia are frequent and unspecific symptoms that need a particularly broad-based interdisciplinary approach to identify potential causes. The attending physician can thereby avoid unnecessary, expensive and somewhat stressful tests.

Optimal timing of oral refeeding in mild acute pancreatitis: results of an open randomized multicenter trial.

Objectives: The aim of this study was to compare 2 protocols regarding the initiation of oral nutrition in patients with mild acute pancreatitis.

Methods: We randomized 143 patients to the Lipase directed (LIP) (n = 74) and the self selected PAT (n = 69) group. In the (PAT) group, the patients restarted eating through self-selection.

Retinotectal ganglion cells in the zebrafish, Danio rerio.

The morphology of retinotectal ganglion cells was investigated by retrograde transport of dextran amines applied into the optic tectum in vitro. Based on criteria such as stratification pattern and size of the dendritic processes, as well as the shape and position of the soma within the dendritic field, three main groups of ganglion cell types with a total of nine different types were identified. The first group included monostratified cells, of which two types (Ma(2) and Mb(5)) may be ON- and OFF-variants, and the third (Mb(6)) had its dendritic field as a narrow band at the inner border of the inner plexiform layer.