Distribution and Maturity of Medial Collagen Fibers in Thoracoabdominal Post-Dissection Aortic Aneurysms: A Comparative Study of Marfan and Non-Marfan Patients.

Thoracoabdominal aortic aneurysms (TAAAs) are rare but serious conditions characterized by dilation of the aorta characterized by remodeling of the vessel wall, with changes in the elastin and collagen content. Individuals with Marfan syndrome have a genetic predisposition for elastic fiber fragmentation and elastin degradation and are prone to early aneurysm formation and progression. Our objective was to analyze the medial collagen characteristics through histological, polarized light microscopy, and electron microscopy methods across the thoracic and abdominal aorta in twenty-five patients undergoing open surgical repair, including nine with Marfan syndrome.

The Validation of the Sinclair Compassion Questionnaire (SCQ) and SCQ Short Form in an English-Speaking U.S. Population: A Patient-Reported Measure of Compassion in Healthcare.

Compassion is recognized as a key component of high-quality healthcare. The literature shows that compassion is essential to improving patient-reported outcomes and fostering health care professionals' (HCPs) response and resilience to burnout. However, compassion is inherently difficult to define, and a validated tool to reliably quantify and measure patients' experience of compassion in healthcare settings did not exist until recently.

Existing evidence on the effect of urban forest management in carbon solutions and avian conservation: a systematic literature map.

Background: Urgent solutions are needed in cities to mitigate twin crises of global climate change and biodiversity loss. Urban nature-based solutions (actions that protect, sustainably manage, and restore ecosystems while simultaneously providing human wellbeing and biodiversity benefits) are being advocated for as multi-functional tools capable of tackling these societal challenges. Urban forest management is a proposed nature-based solution with potential to address both climate change mitigation and biodiversity loss along with multiple other benefits.

Shotgun Bean Bag Projectiles Causing Open Fractures and Retained Radiolucent Foreign Bodies: A Report of 2 Cases.

Case: Bean bag projectiles (BBPs) are less lethal munition composed of a cloth bag filled with lead pellets and marking powder housed in a plastic casing fired from a 12-gauge shot gun. Two patients sustained penetrating BBP injuries that resulted in open fractures and retained BBP. Patient clothing and all BBP components were found deep in the wounds with marking powder surrounding fracture edges.

Solid-state transverse Anderson localized fiber laser.

For the first time, to our knowledge, an all-solid transverse Anderson localizing optical fiber laser is demonstrated. A combination of the molten core and stack-and-draw fiber fabrication techniques is used to produce a 112 µm core diameter fiber that is a random array of Yb-doped high index and passive low index regions. A localized channel first assists in the guidance of amplified spontaneous emission before stimulating laser action, which occurs in the same channel via mixed Anderson localization and step index wave-guiding.

Voluntary Exercise Ameliorates Chronic Ethanol Withdrawal-Induced Adaptations of Opioid Receptor Expression in the Nucleus Accumbens, Dopamine Release, and Ethanol Consumption.

Exercise has increasingly been recognized as an adjunctive therapy for alcohol-use disorder (AUD), yet our understanding of its underlying neurological mechanisms remains limited. This knowledge gap impedes the development of evidence-based exercise guidelines for AUD treatment. Chronic ethanol (EtOH) exposure has been shown to upregulate and sensitize kappa opioid receptors (KORs) in the nucleus accumbens (NAc), which is innervated by dopamine (DA) neurons in the midbrain ventral tegmental area (VTA), which may contribute to AUD-related behaviors.

Motion tracking of fish and bubble clouds in synthetic aperture sonar data.

Data captured by a Synthetic Aperture Sonar (SAS) near Mobile Bay during the 2021 Undersea Remote Sensing experiment funded by the Office of Naval Research reveals near surface bubble clouds from wave breaking events and a large aggregation of fish. Tools developed for using SAS data to image hydrodynamic features in the water column were applied to observations of the bubble clouds and fish aggregation. Combining imagery and height data captured by the sonar array with a detection and tracking algorithm enables the trajectories, velocities, and behavior of fish in the aggregation to be observed.

Interplay of wayfinding strategies in route repetition and route retracing.

This study explores the interplay of navigation strategies in route repetition (repeating a recently travelled route) and route retracing (returning to the start location of a recently travelled route). Specifically, we investigated how sequence knowledge contributes to route repetition and retracing. In the learning phase, participants passively transported along a route.

Differential Expression of MicroRNA (MiR-27, MiR-145) among Dental Pulp Stem Cells (DPSCs) Following Neurogenic Differentiation Stimuli.

This study sought to evaluate the expression of previously identified microRNAs known to regulate neuronal differentiation in mesenchymal stem cells (MSCs), including miR-27, miR-125, miR-128, miR-135, miR-140, miR-145, miR-218 and miR-410, among dental pulp stem cells (DPSCs) under conditions demonstrated to induce neuronal differentiation. Using an approved protocol, = 12 DPSCs were identified from an existing biorepository and treated with basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), which were previously demonstrated to induce neural differentiation markers including Sox1, Pax6 and NFM among these DPSCs. This study revealed that some microRNAs involved in the neuronal differentiation of MSCs were also differentially expressed among the DPSCs, including miR-27 and miR-145.

Three-dimensional observations of tidal plume fronts in estuaries using a synthetic aperture sonar array.

Synthetic aperture sonar (sas) systems are designed to observe stationary scatterers located near the sediment interface. Less commonly, a sas system may be used to observe scattering features located above the sonar in the water column. The Undersea Remote Sensing (USRS) project, sponsored by the Office of Naval Research, was a collaborative Directed Research Initiative (DRI) focused on studying dynamic estuarine water column features.

IFABP levels predict visceral malperfusion in the first hours after open thoracoabdominal aortic repair.

Introduction: Intestinal ischemia after open thoracoabdominal aortic repairs, is a rare but devastating complication, associated with high mortality. Notoriously challenging to diagnose, visceral malperfusion necessitates immediate surgical attention. Intestinal fatty acid-binding protein (IFABP) has been proposed as a biomarker for the diagnosis of intestinal wall damage.

Peer-Assisted Learning in Undergraduate Medical Education for Resilience and Well-being.

Peers are a powerful resource in the learning process. Peer-assisted learning (PAL) is a high value activity for the peer and the coach. We report here a PAL activity focused on resilience and well-being for first-year undergraduate medical students.

Classification of broadband target spectra in the mesopelagic using physics-informed machine learning.

Broadband echosounders measure the scattering response of an organism over a range of frequencies. When compared with acoustic scattering models, this response can provide insight into the type of organism measured. Here, we train the k-Nearest Neighbors algorithm using scattering models and use it to group target spectra (25-40 kHz) measured in the mesopelagic near the New England continental shelf break.

Comparison of mesopelagic organism abundance estimates using in situ target strength measurements and echo-counting techniques.

Recent studies using acoustic techniques suggest that the biomass of mesopelagic fishes may be an order of magnitude higher than previously estimated from trawls. However, there is uncertainty surrounding these estimates, which are derived from shipboard echosounder measurements using necessary, but poorly constrained, assumptions. Here, an echosounder is used to measure individual target strengths at depth.

Frequency- and depth-dependent target strength measurements of individual mesopelagic scatterers.

Recent estimates based on shipboard echosounders suggest that 50% or more of global fish biomass may reside in the mesopelagic zone (depths of ∼200-1000 m). Nonetheless, little is known about the acoustic target strengths (TS) of mesopelagic animals because ship-based measurements cannot resolve individual targets. As a result, biomass estimates of mesopelagic organisms are poorly constrained.

Use of an ether-derived 3-hydroxy-4-pyridinone chelator as a new chromogenic reagent in the development of a microfluidic paper-based analytical device for Fe(III) determination in natural waters.

This article reports on the development and validation of a disposable microfluidic paper-based analytical device (μPAD) for on-hand, in-situ, and cheap Fe(III) determination in natural waters complying with World Health Organization guidelines. The developed μPAD used 3-hydroxy-4-pyridinone (3,4-HPO) as a colour reagent due to its considerably lower toxicity than traditionally used iron analytical reagents. It was selected among a group of hydrophilic 3,4-HPO chelators containing ether-derived chains in their structure which were prepared using green methods.

Effects of the Positive Threshold and Data Analysis on Human MOG Antibody Detection by Live Flow Cytometry.

Human autoantibodies targeting myelin oligodendrocyte glycoprotein (MOG Ab) have become a useful clinical biomarker for the diagnosis of a spectrum of inflammatory demyelinating disorders. Live cell-based assays that detect MOG Ab against conformational MOG are currently the gold standard. Flow cytometry, in which serum binding to MOG-expressing cells and control cells are quantitively evaluated, is a widely used observer-independent, precise, and reliable detection method.

Direct inference of first-year sea ice thickness using broadband acoustic backscattering.

Accurate measurements of sea ice thickness are critical to better understand climate change, to provide situational awareness in ice-covered waters, and to reduce risks for communities that rely on sea ice. Nonetheless, remotely measuring the thickness of sea ice is difficult. The only regularly employed technique that accurately measures the full ice thickness involves drilling a hole through the ice.

THE CONSTRAINING EFFECT OF THE LATERAL FEMORAL INTERMUSCULAR SEPTUM ON PASSIVE HIP ADDUCTION IN UN-EMBALMED CADAVERS.

Background: Due to the lack of verifiable iliotibial band elongation in response to stretching, the anatomical, biomechanical, and physiological responses to treatment of iliotibial band syndrome remain unclear. The lateral intermuscular septum, consisting of multiple myofibroblasts, firmly anchors the iliotibial band to the femur.

Purpose And Hypothesis: The purpose of this in-situ study was to examine the constraining effect of the lateral intermuscular septum on available passive hip adduction range of motion in un-embalmed cadavers.

Observation of optical nonlinearities in an all-solid transverse Anderson localizing optical fiber.

An all-solid transverse Anderson localizing optical fiber (TALOF) was fabricated using a novel combination of the stack-and-draw and molten core methods. Strong Anderson localization is observed in multiple regions of the fiber cross section associated with the higher index strontium aluminosilicate phases randomly arranged within a pure silica matrix. Further, to the best of our knowledge, nonlinear four-wave mixing is reported for the first time in a TALOF.

Acoustic characterization of sensors used for marine environmental monitoring.

Active acoustic sensors are widely used in oceanographic and environmental studies. Although many have nominal operating frequencies above the range of marine mammal hearing, they can produce out-of-band sound that may be audible to marine mammals. Acoustic emissions from four active acoustic transducers were characterized and compared to marine mammal hearing thresholds.

Acoustically relevant properties of four crude oils at oceanographic temperatures and pressures.

Inversions of models of broadband acoustic scattering to detect and quantify weakly scattering targets, such as oil droplets in seawater, require precise knowledge of the physical properties that determine scattering. When the characteristic impedance contrast between a target and the surrounding medium is weak, small differences between the true and modeled impedance can cause significant errors in modeled scattering. For crude oil, currently available empirical models of density and sound speed are derived from measurements made at reservoir conditions (high temperature and pressure), which may not be relevant to oceanographic conditions due to phase changes in the oil.

Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults.

Background: Recent studies suggest curcumin is a promising nutraceutical for improving important clinical and physiological markers of healthy aging, including motor and cognitive function.

Objective: To determine if curcumin supplementation improves motor and cognitive function in healthy middle-aged and older adults.

Methods: 39 healthy men and postmenopausal women (45-74 yrs) were randomized to 12 weeks of placebo ( = 19) or curcumin supplementation (2000 mg/day Longvida;  = 20) with motor and cognitive function assessed at week 0 and 12.