Bioactive polyphenols in kinkéliba tea (Combretum micranthum) and their glucose-lowering activities.

Herbal tea kinkéliba prepared from the leaves of Combretum micranthum has been widely consumed in West African countries for its flavor, nutritional and medicinal properties. Under bio-guided screening, the kinkéliba leaves were chemically investigated using various chromatographic and spectrometric methods that led to the identification of thirteen different flavonoid compounds. Further biological tests illustrated that the identified compounds may have synergistic effects to decrease the expression of phosphoenolpyruvate carboxykinase (PEPCK) mRNA and glucose production in an H4IIE hepatoma cell line, indicating its potential use for insulin-resistant diabetes treatment.

PHYTOCHEMICAL SCREENING, ANTIMICROBIAL AND CYTOTOXICITY STUDIES OF ETHANOL LEAF EXTRACT OF ().

Background: is commonly used in Senegalese traditional medicine to treat pain, inflammation, asthenia, bacterial and fungal infections. The aim of this study was to determine the type of phytochemical constituents present in the ethanol leaf extract and its antimicrobial activity against selected bacterial and fungal pathogens.

Materials And Methods: The ethanol leaf extract of .

Antidiabetic properties of aqueous barks extract of Parinari excelsa in alloxan-induced diabetic rats.

The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a significant decrease of blood glucose on glucose-loaded normoglycaemic rats.

[Myorelaxant and antispasmodic activity of ethanolic total extract's fractions of roots of Cassia sieberiana D.C. (Caesalpiniaceae) on isolated wistar rat ileum].

Introduction: Cassia sieberiana DC (CAESALPINIACEAE) is a plant which grows in Southern Senegal. Its roots are used by traditional medicinal practitioners for its s pasmolytic and antiparasitic properties. The objective of our study was to investigate the myorelaxant and antispasmodic activity of the roots of C.

[Experimental evidence of against cough activity of total alkaloids from Guiera senegalensis Lam. in guinea pig;].

Introduction: Against cough activity from Guiera senegalensis' leaves has been previously scientifically studied. However, to the best of our knowledge, active principles responsible of this activity were not yet identified. Thus, we undertook this work with the aim to evaluate the effect of total alkaloids from plant's leaves in cough induced in guinea pig by ammoniac inhalation.

[Antipyretic effect of aqueous extract and alcaloid of Tinospora bakis (Miers) in rabbits].

Lyophilised aqueous extract and alcaloidic totum (basic form) from roots of Tinospora bakis (Miers) have been tested with hyperthermic rabbits by sub-cutaneous administration of Saccharomyces cerevisiae mixture at 2g/kg. Total aqueous extract had been orally administrated at three doses: 150, 300 and 600 mg/kg and we obtained significant antipyretic effects at 300 and 600 mg/kg. With the alcaloidic totum at 2.

[Preparation of a syrup with Bakis roots (Tinospora bakis) and evaluation of its choleretic activity in rats].

The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity.

[Toxocological study of Guiera senegalensis Lam (Combretaceae)].

The study was based on an aqueous extract derived from a 60 degrees ethanolic tincture containing 0.032 g of dry matter per ml. The leaves of Guiera senegalensis Lam (Combretaceae) were collected in December 1991 at Nguekhokh a village within 20 km from Mbour (Senegal).

Primary prevention with cotrimoxazole for HIV-1-infected adults: results of the pilot study in Dakar, Senegal.

Objectives: To assess the efficacy and tolerance of chemoprophylaxis with cotrimoxazole compared with placebo among HIV-1-infected adults.

Design: Randomized, double-blind, placebo-controlled clinical trial in the urban community of Dakar, Senegal.

Methods: Eligibility criteria were age greater than 15 years, HIV-1 or HIV-1 and HIV-2 dual seropositivity, CD4 cell count lower than 400 copies/mm3, no progressive infection, no previous history of intolerance to sulphonamide, lack of severe anemia or neutropenia, and renal or hepatic failure.

[Application of phytotherapy in odontology: the case of Euphorbia balsamifera. Endodontic clinical trial].

Phytotherapy is a medicinal and ancestral practice in Africa. It deals with all the fields of human pathology. We wanted to ascertain the efficacy of some plants used in odontology as Euphorbia balsamifera traditionally used as antalgic treatment of acute dental pulpitis.

[Antibacterial activity of essential oils from mint in Senegal].

Three species of the Mentha gender are found in Senegal under the name of "Nana", and are essentially used in tea and juices as flavour. The aerial parts of the three species (common mint, mentholated mint and "fass" mint) have been harvested two months after they have been sown and the extraction of the essential oils was done by carrying them away with water vapour by hydrodistillation. The essential oils were used to study the antibacterial potency (typing of the Minimal Inhibitory concentrations-MIC) by the agar dilution method.

[Purgative activity of Cassia italica].

Twenty guinea pigs were used to study the effects of Cassia italica leaves and pods extracts on intestinal motricity in vitro. The results obtained showed that the plant stimulate intestinal contractions with dose-dependent relation. Moreover, Cassia italica contractile activity was comparable to the acetylcholine one and was inhibited by atropine.

[Choleretic effects of Cassia alata Linn in the rat].

Fifty rats weighing average 200 g were used to study choleretic activity of Cassia alata LINN extract. Bile was collected according to acute biliarly fistula technic on animals anesthetized with 1.5g/kg of ethyle carbamate (Urethane ND).

[Senegalese pharmacopoeia: study of acute toxicity and antitussive activity of Calotropis procera AIT (Asclepiadaceae)].

We confirmed the innocuity of different extracts (leaves and stem bark) of Calotropis procera (Asclepiadaceae), a plant widely used in Asian and West African traditional therapy in dermatological and bronchal affections. We proved the against cough activity of the aqueous stem bark extract after administration, per os, upon bronchal irritation by ammoniac on Guinea Pig.

[Antihypertensive action of Parkia biglobosa+ (Jacq) Benth seeds in the rat].

Hundred white Wistar rats have been used to evaluate the antihypertensive effects of entire seeds and decorticated, fermented seeds of a soudanian plant, Parkia biglobosa. The arterial blood pressure was measured by using bloody method in anesthizied animals. The Pham Huu Chanh method was used to determine type plant's antihypertensive activity.