Publications by authors named "Bassem Attalla"
Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, is indicated to improve glycaemic control in adults of type 2 diabetes. In nonclinical studies, dapagliflozin was neither genotoxic nor carcinogenic. However, in some clinical studies, an increased incidence of bladder cancer was observed in the dapagliflozin group vs.
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- - The study developed a 2-stage model to explore urinary bladder cancer in male Sprague-Dawley rats by first initiating tumors with a chemical called BBN and then testing potential tumor promoters over a 26-week period.
- - Rats treated with rosiglitazone and uracil showed a significant increase in bladder tumors, with uracil being the most effective, leading to a high percentage of transitional cell carcinomas (TCCs).
- - Sodium ascorbate appeared to have a protective effect, reducing the development of bladder cell hyperplasia without promoting tumor formation, confirming the model's effectiveness in identifying tumor promoters.
Prolonged treatment with human parathyroid hormone (hPTH) in rats results in development of bone tumors, though this finding has not been supported by clinical experience. The PTH type 1 receptor agonist abaloparatide, selected for its bone anabolic activity, is under clinical development to treat postmenopausal women with osteoporosis. To determine the carcinogenic potential of abaloparatide, Fischer (F344) rats were administered SC daily abaloparatide at doses of 0, 10, 25, and 50 μg/kg or 30 μg/kg hPTH(1-34) as a positive control for up to 2 years.
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